Superficial Collagen Fibril Modulus and Pericellular Fixed Charge Density Modulate Chondrocyte Volumetric Behaviour in Early Osteoarthritis

Simple item page
dc.contributor.authorTanska, Petri
dc.contributor.authorTurunen, Siru M.
dc.contributor.authorHan, Sang Kuy
dc.contributor.authorJulkunen, Petro
dc.contributor.authorHerzog, Walter
dc.contributor.authorKorhonen, Rami K.
dc.date.accessioned2018-09-27T11:42:30Z
dc.date.available2018-09-27T11:42:30Z
dc.date.issued2013-03-24
dc.date.updated2018-09-27T11:42:30Z
dc.description.abstractThe aim of this study was to investigate if the experimentally detected altered chondrocyte volumetric behavior in early osteoarthritis can be explained by changes in the extracellular and pericellular matrix properties of cartilage. Based on our own experimental tests and the literature, the structural and mechanical parameters for normal and osteoarthritic cartilage were implemented into a multiscale fibril-reinforced poroelastic swelling model. Model simulations were compared with experimentally observed cell volume changes in mechanically loaded cartilage, obtained from anterior cruciate ligament transected rabbit knees. We found that the cell volume increased by 7% in the osteoarthritic cartilage model following mechanical loading of the tissue. In contrast, the cell volume decreased by 4% in normal cartilage model. These findings were consistent with the experimental results. Increased local transversal tissue strain due to the reduced collagen fibril stiffness accompanied with the reduced fixed charge density of the pericellular matrix could increase the cell volume up to 12%. These findings suggest that the increase in the cell volume in mechanically loaded osteoarthritic cartilage is primarily explained by the reduction in the pericellular fixed charge density, while the superficial collagen fibril stiffness is suggested to contribute secondarily to the cell volume behavior.
dc.description.versionPeer Reviewed
dc.identifier.citationPetri Tanska, Siru M. Turunen, Sang Kuy Han, Petro Julkunen, Walter Herzog, and Rami K. Korhonen, “Superficial Collagen Fibril Modulus and Pericellular Fixed Charge Density Modulate Chondrocyte Volumetric Behaviour in Early Osteoarthritis,” Computational and Mathematical Methods in Medicine, vol. 2013, Article ID 164146, 14 pages, 2013. doi:10.1155/2013/164146
dc.identifier.doihttps://doi.org/10.1155/2013/164146
dc.identifier.urihttp://hdl.handle.net/1880/108276
dc.identifier.urihttps://doi.org/10.11575/PRISM/44769
dc.language.rfc3066en
dc.rights.holderCopyright © 2013 Petri Tanska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleSuperficial Collagen Fibril Modulus and Pericellular Fixed Charge Density Modulate Chondrocyte Volumetric Behaviour in Early Osteoarthritis
dc.typeJournal Article
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
CMMM.2013.164146.pdf
Size:
1.65 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
0 B
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Open Access Publications