Opposite Dynamics of GABA and Glutamate Levels in the Occipital Cortex during Visual Processing

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dc.contributor.authorKurcyus, Katarzyna
dc.contributor.authorAnnac, Efsun
dc.contributor.authorHanning, Nina M.
dc.contributor.authorHarris, Ashley D.
dc.contributor.authorOeltzschner, George
dc.contributor.authorEdden, Richard
dc.contributor.authorRiedl, Valentin
dc.date.accessioned2021-01-06T20:50:52Z
dc.date.available2021-01-06T20:50:52Z
dc.date.issued2018-10-03
dc.description.abstractMagnetic resonance spectroscopy (MRS) measures the two most common inhibitory and excitatory neurotransmitters, GABA and glutamate, in the human brain. However, the role of MRS-derived GABA and glutamate signals in relation to system-level neural signaling and behavior is not fully understood. In this study, we investigated levels of GABA and glutamate in the visual cortex of healthy human participants (both genders) in three functional states with increasing visual input. Compared with a baseline state of eyes closed, GABA levels decreased after opening the eyes in darkness and Glx levels remained stable during eyes open but increased with visual stimulation. In relevant states, GABA and Glx correlated with amplitude of fMRI signal fluctuations. Furthermore, visual discriminatory performance correlated with the level of GABA, but not Glx. Our study suggests that differences in brain states can be detected through the contrasting dynamics of GABA and Glx, which has implications in interpreting MRS measurements.
dc.description.grantingagencyOther
dc.identifier.citationKurcyus, K., Annac, E., Hanning, N. M., Harris, A. D., Oeltzschner, G., Edden, R., & Riedl, V. (2018). Opposite Dynamics of GABA and Glutamate Levels in the Occipital Cortex during Visual Processing. The Journal of Neuroscience, 38(46), 9967–9976. https://doi.org/10.1523/jneurosci.1214-18.2018
dc.identifier.doi10.1523/jneurosci.1214-18.2018
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/38517
dc.identifier.issn0270-6474
dc.identifier.urihttp://hdl.handle.net/1880/112925
dc.language.isoeng
dc.publisherSociety for Neuroscience
dc.publisher.hasversionPublisher's version
dc.publisher.policyhttps://www.jneurosci.org/content/information-authors#policies
dc.rights© 2018 the author
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectfMRS
dc.subjectGABA
dc.subjectglutamate
dc.subjectrs-fMRI
dc.subjectvisual discriminatory performance
dc.subjectvisual system
dc.titleOpposite Dynamics of GABA and Glutamate Levels in the Occipital Cortex during Visual Processing
dc.typejournal article
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