A Preliminary Study of the Influence of Age of Onset and Childhood Trauma on Cortical Thickness in Major Depressive Disorder

dc.contributor.authorJaworska, Natalia
dc.contributor.authorMacMaster, Frank P.
dc.contributor.authorGaxiola, Ismael
dc.contributor.authorCortese, Filomeno
dc.contributor.authorGoodyear, Bradley
dc.contributor.authorRamasubbu, Rajamannar
dc.date.accessioned2018-09-27T11:33:51Z
dc.date.available2018-09-27T11:33:51Z
dc.date.issued2014-03-06
dc.date.updated2018-09-27T11:33:51Z
dc.description.abstractBackground. Major depressive disorder (MDD) neural underpinnings may differ based on onset age and childhood trauma. We assessed cortical thickness in patients who differed in age of MDD onset and examined trauma history influence. Methods. Adults with MDD () and controls (HC; ) underwent magnetic resonance imaging. Twenty patients had MDD onset 24 years of age (pediatric onset) and 16 had onset 25 years of age (adult onset). The MDD group was also subdivided into those with () and without () physical and/or sexual abuse as assessed by the Childhood Trauma Questionnaire (CTQ). Cortical thickness was analyzed with FreeSurfer software. Results. Thicker frontal pole and a tendency for thinner transverse temporal cortices existed in MDD. The former was driven by the pediatric onset group and abuse history (independently), particularly in the right frontal pole. Inverse correlations existed between CTQ scores and frontal pole cortex thickness. A similar inverse relation existed with left inferior and right superior parietal cortex thickness. The superior temporal cortex tended to be thinner in pediatric versus adult onset groups with childhood abuse. Conclusions. This preliminary work suggests neural differences between pediatric and adult MDD onset. Trauma history also contributes to cytoarchitectural modulation. Thickened frontal pole cortices as a compensatory mechanism in MDD warrant evaluation.
dc.description.versionPeer Reviewed
dc.identifier.citationNatalia Jaworska, Frank P. MacMaster, Ismael Gaxiola, Filomeno Cortese, Bradley Goodyear, and Rajamannar Ramasubbu, “A Preliminary Study of the Influence of Age of Onset and Childhood Trauma on Cortical Thickness in Major Depressive Disorder,” BioMed Research International, vol. 2014, Article ID 410472, 9 pages, 2014. doi:10.1155/2014/410472
dc.identifier.doihttps://doi.org/10.1155/2014/410472
dc.identifier.urihttp://hdl.handle.net/1880/108201
dc.language.rfc3066en
dc.rights.holderCopyright © 2014 Natalia Jaworska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleA Preliminary Study of the Influence of Age of Onset and Childhood Trauma on Cortical Thickness in Major Depressive Disorder
dc.typeJournal Article
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