Detection of reduced interhemispheric cortical communication during task execution in multiple sclerosis patients using functional near-infrared spectroscopy

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dc.contributor.authorJimenez, Jon J
dc.contributor.authorYang, Runze
dc.contributor.authorNathoo, Nabeela
dc.contributor.authorVarshney, Vishal P
dc.contributor.authorGolestani, Ali-Mohammad
dc.contributor.authorMetz, Luanne M
dc.contributor.authorDunn, Jeff F
dc.date.accessioned2017-03-13T21:59:14Z
dc.date.available2017-03-13T21:59:14Z
dc.date.issued2014-07-08
dc.description.abstractMultiple sclerosis (MS) impairs brain activity through demyelination and loss of axons. Increased brain activity is accompanied by increases in microvascular hemoglobin oxygen saturation (oxygenation) and total hemoglobin, which can be measured using functional near-infrared spectroscopy (fNIRS). Due to the potentially reduced size and integrity of the white matter tracts within the corpus callosum, it may be expected that MS patients have reduced functional communication between the left and right sides of the brain; this could potentially be an indicator of disease progression. To assess interhemispheric communication in MS, we used fNIRS during a unilateral motor task and the resting state. The magnitude of the change in hemoglobin parameters in the motor cortex was significantly reduced in MS patients during the motor task relative to healthy control subjects. There was also a significant decrease in interhemispheric communication between the motor cortices (expressed as coherence) in MS patients compared to controls during the motor task, but not during the resting state. fNIRS assessment of interhemispheric coherence during task execution may be a useful marker in disorders with white matter damage or axonal loss, including MS.en_US
dc.description.grantingagencyMultiple Sclerosis Society of Canada, Alberta endMS Regional Research and Training Centre of the endMS Research and Training Network, National Science and Engineering Research Council of Canada, Alberta Innovates-Health Solutionsen_US
dc.description.refereedYesen_US
dc.identifier.citationJimenez et al. Detection of reduced interhemispheric cortical communication during task execution in multiple sclerosis patients using functional near-infrared spectroscopy. Journal of Biomedical Optics 19(7), 076008 (July 2014).en_US
dc.identifier.doi10.1117/1.JBO.19.7.076008.
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33485
dc.identifier.issn1083-3668
dc.identifier.urihttp://hdl.handle.net/1880/51853
dc.language.isoenen_US
dc.publisherSociety of Photo-optical Instrumentation Engineersen_US
dc.publisher.corporateUniversity of Calgary
dc.publisher.departmentRadiologyen_US
dc.publisher.facultyMedicineen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.subjectcoherenceen_US
dc.subjectdemyelinationen_US
dc.subjectfunctional near-infrared spectroscopyen_US
dc.subjectmotor cortexen_US
dc.subjectmultiple sclerosisen_US
dc.subjectnear-infrared spectroscopyen_US
dc.titleDetection of reduced interhemispheric cortical communication during task execution in multiple sclerosis patients using functional near-infrared spectroscopyen_US
dc.typejournal article
thesis.degree.disciplineRadiology / Physiology / Clinical Neurosciences
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