Quantification of lung water in heart failure using cardiovascular magnetic resonance imaging
dc.contributor.author | Thompson, Richard B | |
dc.contributor.author | Chow, Kelvin | |
dc.contributor.author | Pagano, Joseph J | |
dc.contributor.author | Sekowski, Viktor | |
dc.contributor.author | Michelakis, Evangelos D. | |
dc.contributor.author | Tymchak, Wayne | |
dc.contributor.author | Haykowsky, Mark J | |
dc.contributor.author | Ezekowitz, Justin A | |
dc.contributor.author | Oudit, Gavin Y | |
dc.contributor.author | Dyck, Jason R B | |
dc.contributor.author | Kaul, Padma | |
dc.contributor.author | Savu, Anamaria | |
dc.contributor.author | Paterson, D. I | |
dc.date.accessioned | 2019-09-15T00:02:30Z | |
dc.date.available | 2019-09-15T00:02:30Z | |
dc.date.issued | 2019-09-12 | |
dc.date.updated | 2019-09-15T00:02:30Z | |
dc.description.abstract | Abstract Background Pulmonary edema is a cardinal feature of heart failure but no quantitative tests are available in clinical practice. The goals of this study were to develop a simple cardiovascular magnetic resonance (CMR) approach for lung water quantification, to correlate CMR derived lung water with intra-cardiac pressures and to determine its prognostic significance. Methods Lung water density (LWD, %) was measured using a widely available single-shot fast spin-echo acquisition in two study cohorts. Validation Cohort: LWD was compared to left ventricular end-diastolic pressure or pulmonary capillary wedge pressure in 19 patients with heart failure undergoing cardiac catheterization. Prospective Cohort: LWD was measured in 256 subjects, including 121 with heart failure, 82 at-risk for heart failure and 53 healthy controls. Clinical outcomes were evaluated up to 1 year. Results Within the validation cohort, CMR LWD correlated to invasively measured left-sided filling pressures (R = 0.8, p < 0.05). In the prospective cohort, mean LWD was 16.6 ± 2.1% in controls, 17.9 ± 3.0% in patients at-risk and 19.3 ± 5.4% in patients with heart failure, p < 0.001. In patients with or at-risk for heart failure, LWD > 20.8% (mean + 2 standard deviations of healthy controls) was an independent predictor of death, hospitalization or emergency department visit within 1 year, hazard ratio 2.4 (1.1–5.1, p = 0.03). Conclusions In patients with heart failure, increased CMR-derived lung water is associated with increased intra-cardiac filling pressures, and predicts 1 year outcomes. LWD could be incorporated in standard CMR scans. | |
dc.identifier.citation | Journal of Cardiovascular Magnetic Resonance. 2019 Sep 12;21(1):58 | |
dc.identifier.doi | https://doi.org/10.1186/s12968-019-0567-y | |
dc.identifier.uri | http://hdl.handle.net/1880/110930 | |
dc.identifier.uri | https://doi.org/10.11575/PRISM/44811 | |
dc.language.rfc3066 | en | |
dc.rights.holder | The Author(s). | |
dc.title | Quantification of lung water in heart failure using cardiovascular magnetic resonance imaging | |
dc.type | Journal Article |