Quantification of lung water in heart failure using cardiovascular magnetic resonance imaging

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dc.contributor.authorThompson, Richard B
dc.contributor.authorChow, Kelvin
dc.contributor.authorPagano, Joseph J
dc.contributor.authorSekowski, Viktor
dc.contributor.authorMichelakis, Evangelos D.
dc.contributor.authorTymchak, Wayne
dc.contributor.authorHaykowsky, Mark J
dc.contributor.authorEzekowitz, Justin A
dc.contributor.authorOudit, Gavin Y
dc.contributor.authorDyck, Jason R B
dc.contributor.authorKaul, Padma
dc.contributor.authorSavu, Anamaria
dc.contributor.authorPaterson, D. I
dc.date.accessioned2019-09-15T00:02:30Z
dc.date.available2019-09-15T00:02:30Z
dc.date.issued2019-09-12
dc.date.updated2019-09-15T00:02:30Z
dc.description.abstractAbstract Background Pulmonary edema is a cardinal feature of heart failure but no quantitative tests are available in clinical practice. The goals of this study were to develop a simple cardiovascular magnetic resonance (CMR) approach for lung water quantification, to correlate CMR derived lung water with intra-cardiac pressures and to determine its prognostic significance. Methods Lung water density (LWD, %) was measured using a widely available single-shot fast spin-echo acquisition in two study cohorts. Validation Cohort: LWD was compared to left ventricular end-diastolic pressure or pulmonary capillary wedge pressure in 19 patients with heart failure undergoing cardiac catheterization. Prospective Cohort: LWD was measured in 256 subjects, including 121 with heart failure, 82 at-risk for heart failure and 53 healthy controls. Clinical outcomes were evaluated up to 1 year. Results Within the validation cohort, CMR LWD correlated to invasively measured left-sided filling pressures (R = 0.8, p < 0.05). In the prospective cohort, mean LWD was 16.6 ± 2.1% in controls, 17.9 ± 3.0% in patients at-risk and 19.3 ± 5.4% in patients with heart failure, p < 0.001. In patients with or at-risk for heart failure, LWD >  20.8% (mean + 2 standard deviations of healthy controls) was an independent predictor of death, hospitalization or emergency department visit within 1 year, hazard ratio 2.4 (1.1–5.1, p = 0.03). Conclusions In patients with heart failure, increased CMR-derived lung water is associated with increased intra-cardiac filling pressures, and predicts 1 year outcomes. LWD could be incorporated in standard CMR scans.
dc.identifier.citationJournal of Cardiovascular Magnetic Resonance. 2019 Sep 12;21(1):58
dc.identifier.doihttps://doi.org/10.1186/s12968-019-0567-y
dc.identifier.urihttp://hdl.handle.net/1880/110930
dc.language.rfc3066en
dc.rights.holderThe Author(s).
dc.titleQuantification of lung water in heart failure using cardiovascular magnetic resonance imaging
dc.typeJournal Article
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