The Potential Clinical Utility of Serum and Peritoneal C-Reactive Protein (CRP) Measurement in Trauma and Critically Ill Patients
Date
2019-07
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
C reactive protein (CRP) levels remain an enigma in the prognostication and management of trauma patients. Several studies have suggested that serum and peritoneal CRP levels may be associated with and predict morbidity and mortality. Other studies have raised doubts on these findings. A clear recognition of the critical role of CRP is required. We conducted a systematic review to investigate the role of serum CRP in trauma patients in predicting sepsis, organ failure and mortality. In addition, we investigated the association between serum CRP levels and ISS (injury Severity Score). A second study was conducted to evaluate the potential utility of serum and peritoneal CRP in predicting clinical outcomes in trauma and critically ill patients. Studies supported the association between high CRP measurements with clinical outcomes including sepsis and organ failure. High peritoneal CRP levels was associated with mortality in critically ill patients. In conclusion, CRP measurements may help identify patients at high risk who may benefit from more intense physiologic monitoring. Peritoneal CRP is a promising diagnostic tool in the assessment of the critically ill and injured.
Description
Keywords
C-Reactive Protein, Critical Care, biomarkers, peritoneal, Temporary Abdominal Closure, Trauma
Citation
Al Hinai, F. (2019). The Potential Clinical Utility of Serum and Peritoneal C-Reactive Protein (CRP) Measurement in Trauma and Critically Ill Patients (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.