The Potential Clinical Utility of Serum and Peritoneal C-Reactive Protein (CRP) Measurement in Trauma and Critically Ill Patients

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dc.contributor.advisorKirkpatrick, Andrew Wallace W.
dc.contributor.authorAl Hinai, Fatma
dc.contributor.committeememberDoig, Christopher James
dc.contributor.committeememberBall, Chad G.
dc.date2019-11
dc.date.accessioned2019-09-12T21:20:13Z
dc.date.available2019-09-12T21:20:13Z
dc.date.issued2019-07
dc.description.abstractC reactive protein (CRP) levels remain an enigma in the prognostication and management of trauma patients. Several studies have suggested that serum and peritoneal CRP levels may be associated with and predict morbidity and mortality. Other studies have raised doubts on these findings. A clear recognition of the critical role of CRP is required. We conducted a systematic review to investigate the role of serum CRP in trauma patients in predicting sepsis, organ failure and mortality. In addition, we investigated the association between serum CRP levels and ISS (injury Severity Score). A second study was conducted to evaluate the potential utility of serum and peritoneal CRP in predicting clinical outcomes in trauma and critically ill patients. Studies supported the association between high CRP measurements with clinical outcomes including sepsis and organ failure. High peritoneal CRP levels was associated with mortality in critically ill patients. In conclusion, CRP measurements may help identify patients at high risk who may benefit from more intense physiologic monitoring. Peritoneal CRP is a promising diagnostic tool in the assessment of the critically ill and injured.en_US
dc.identifier.citationAl Hinai, F. (2019). The Potential Clinical Utility of Serum and Peritoneal C-Reactive Protein (CRP) Measurement in Trauma and Critically Ill Patients (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/36986
dc.identifier.urihttp://hdl.handle.net/1880/110914
dc.language.isoengen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.institutionUniversity of Calgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en_US
dc.subjectC-Reactive Proteinen_US
dc.subjectCritical Careen_US
dc.subjectbiomarkersen_US
dc.subjectperitonealen_US
dc.subjectTemporary Abdominal Closureen_US
dc.subjectTraumaen_US
dc.subject.classificationMedicine and Surgeryen_US
dc.titleThe Potential Clinical Utility of Serum and Peritoneal C-Reactive Protein (CRP) Measurement in Trauma and Critically Ill Patientsen_US
dc.typemaster thesisen_US
thesis.degree.disciplineMedicine – Medical Sciencesen_US
thesis.degree.grantorUniversity of Calgaryen_US
thesis.degree.nameMaster of Science (MSc)en_US
ucalgary.item.requestcopytrueen_US
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