Cav3.2 T-type calcium channels control acute itch in mice
| dc.contributor.author | Gadotti, Vinicius M | |
| dc.contributor.author | Kreitinger, Joanna M | |
| dc.contributor.author | Wageling, Nicholas B | |
| dc.contributor.author | Budke, Dylan | |
| dc.contributor.author | Diaz, Philippe | |
| dc.contributor.author | Zamponi, Gerald W | |
| dc.date.accessioned | 2020-09-06T00:09:25Z | |
| dc.date.available | 2020-09-06T00:09:25Z | |
| dc.date.issued | 2020-09-01 | |
| dc.date.updated | 2020-09-06T00:09:25Z | |
| dc.description.abstract | Abstract Cav3.2 T-type calcium channels are important mediators of nociceptive signaling, but their roles in the transmission of itch remains poorly understood. Here we report a key involvement of these channels as key modulators of itch/pruritus-related behavior. We compared scratching behavior responses between wild type and Cav3.2 null mice in models of histamine- or chloroquine-induced itch. We also evaluated the effect of the T-type calcium channel blocker DX332 in male and female wild-type mice injected with either histamine or chloroquine. Cav3.2 null mice exhibited decreased scratching responses during both histamine- and chloroquine-induced acute itch. DX332 co-injected with the pruritogens inhibited scratching responses of male and female mice treated with either histamine or chloroquine. Altogether, our data provide strong evidence that Cav3.2 T-type channels exert an important role in modulating histamine-dependent and -independent itch transmission in the primary sensory afferent pathway, and highlight these channels as potential pharmacological targets to treat pruritus. | |
| dc.identifier.citation | Molecular Brain. 2020 Sep 01;13(1):119 | |
| dc.identifier.doi | https://doi.org/10.1186/s13041-020-00663-9 | |
| dc.identifier.uri | http://hdl.handle.net/1880/112498 | |
| dc.language.rfc3066 | en | |
| dc.rights.holder | The Author(s) | |
| dc.title | Cav3.2 T-type calcium channels control acute itch in mice | |
| dc.type | Journal Article |