Manipulating visual scanpaths during facial emotion perception modulates functional brain activation in schizophrenia patients and controls

Spilka, Michael J.; Pittman, Daniel J.; Bray, Signe L.; Goghari, Vina M.

Manipulating visual scanpaths during facial emotion perception modulates functional brain activation in schizophrenia patients and controls

dc.contributor.author	Spilka, Michael J.
dc.contributor.author	Pittman, Daniel J.
dc.contributor.author	Bray, Signe L.
dc.contributor.author	Goghari, Vina M.
dc.date.accessioned	2019-09-26T18:12:14Z
dc.date.available	2019-09-26T18:12:14Z
dc.date.issued	2019-09
dc.description.abstract	Individuals with schizophrenia exhibit deficits in facial emotion processing, which have been associated with abnormalities in visual gaze behaviour and functional brain activation. However, the relationship between gaze behaviour and brain activation in schizophrenia remains unexamined. Studies in healthy individuals and other clinical samples indicate a relationship between gaze behaviour and functional activation in brain regions implicated in facial emotion processing deficits in schizophrenia (e.g., fusiform gyrus), prompting the question of whether a similar relationship exists in schizophrenia. This study examined whether manipulating visual scanpaths during facial emotion perception would modulate functional brain activation in a sample of 23 schizophrenia patients and 26 community controls. Participants underwent functional magnetic resonance imaging while viewing pictures of emotional faces. During the typical viewing condition, a fixation cue directed participants’ gaze primarily to the eyes and mouth, whereas during the atypical viewing condition gaze was directed to peripheral features. Both viewing conditions elicited a robust response throughout face-processing regions. Typical viewing led to greater activation in visual association cortex including the right inferior occipital gyrus/occipital face area, whereas atypical viewing elicited greater activation in primary visual cortex and regions involved in attentional control. There were no between-group activation differences in response to faces or interaction between group and gaze manipulation. The results indicate that gaze behaviour modulates functional activation in early face-processing regions in individuals with and without schizophrenia, suggesting that abnormal gaze behaviour in schizophrenia may contribute to activation abnormalities during facial emotion perception.	en_US
dc.identifier.citation	Spilka, M. J., Pittman, D. J., Bray, S. L., & Goghari, V. M. (2019). Manipulating visual scanpaths during facial emotion perception modulates functional brain activation in schizophrenia patients and controls. "American Psychological Association". 1-40. http://dx.doi.org/10.1037/abn0000468	en_US
dc.identifier.doi	http://dx.doi.org/10.1037/abn0000468	en_US
dc.identifier.uri	http://hdl.handle.net/1880/111079
dc.identifier.uri	https://doi.org/10.11575/PRISM/43666
dc.language.iso	eng	en_US
dc.publisher.department	Psychology	en_US
dc.publisher.faculty	Arts	en_US
dc.publisher.institution	University of Calgary	en_US
dc.rights	Unless otherwise indicated, this material is protected by copyright and has been made available with authorization from the copyright owner. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.	en_US
dc.subject	eye tracking	en_US
dc.subject	facial emotion perception	en_US
dc.subject	fMRI	en_US
dc.subject	OFA	en_US
dc.subject	psychosis	en_US
dc.title	Manipulating visual scanpaths during facial emotion perception modulates functional brain activation in schizophrenia patients and controls	en_US
dc.type	journal article	en_US
dc.type	acceptedVersion	en_US
ucalgary.item.requestcopy	true	en_US