GABA Levels in Left and Right Sensorimotor Cortex Correlate across Individuals

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dc.contributor.authorPuts, Nicholaas A.J.
dc.contributor.authorHeba, Stefanie
dc.contributor.authorHarris, Ashley D.
dc.contributor.authorEvans, Christopher J.
dc.contributor.authorMcGonigle, David J.
dc.contributor.authorTegenthoff, Martin
dc.contributor.authorSchmidt-Wilcke, Tobias
dc.contributor.authorEdden, Richard A.E.
dc.date.accessioned2021-01-06T20:50:55Z
dc.date.available2021-01-06T20:50:55Z
dc.date.issued2018-07-24
dc.description.abstractDifferences in -aminobutyric acid (GABA) levels measured with Magnetic Resonance Spectroscopy have been shown to correlate with behavioral performance over a number of tasks and cortical regions. These correlations appear to be regionally and functionally specific. In this study, we test the hypothesis that GABA levels will be correlated within individuals for functionally related regionsthe left and right sensorimotor cortex. In addition, we investigate whether this is driven by bulk tissue composition. GABA measurements using edited MRS data were acquired from the left and right sensorimotor cortex in 24 participants. T1-weighted MR images were also acquired and segmented to determine the tissue composition of the voxel. GABA level is shown to correlate significantly between the left and right regions (r = 0.64, p < 0.03). Tissue composition is highly correlated between sides, but does not explain significant variance in the bilateral correlation. In conclusion, individual differences in GABA level, which have previously been described as functionally and regionally specific, are correlated between homologous sensorimotor regions. This correlation is not driven by bulk differences in voxel tissue composition.
dc.description.grantingagencyOther
dc.identifier.citationPuts, N., Heba, S., Harris, A., Evans, C., McGonigle, D., Tegenthoff, M., Schmidt-Wilcke, T., & Edden, R. (2018). GABA Levels in Left and Right Sensorimotor Cortex Correlate across Individuals. Biomedicines, 6(3), 80. https://doi.org/10.3390/biomedicines6030080
dc.identifier.doi10.3390/biomedicines6030080
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/38523
dc.identifier.issn2227-9059
dc.identifier.urihttp://hdl.handle.net/1880/112931
dc.language.isoeng
dc.publisherMDPI AG
dc.publisher.hasversionPublisher's version
dc.publisher.policyhttps://www.mdpi.com/about/openaccess
dc.rights© 2018 by the authors.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectGABA
dc.subjectMRS
dc.subjectsensorimotor
dc.subjectindividual differences
dc.subjectbilateral inhibition
dc.titleGABA Levels in Left and Right Sensorimotor Cortex Correlate across Individuals
dc.typejournal article
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