Accumulation of Trospectomycin by Strains of Salmonella typhimurium, escherichia coli and Haemophilus influenzae

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dc.contributor.authorWong, S
dc.contributor.authorBryan, LE
dc.date.accessioned2018-09-27T12:33:06Z
dc.date.available2018-09-27T12:33:06Z
dc.date.issued1990-01-01
dc.date.updated2018-09-27T12:33:06Z
dc.description.abstractTrospectomycin, unlike aminoglycosidic aminocyclitols, is accumulated by a nonsaturable, energy-independent, diffusional process in Salmonella typhimurium, Escherichia coli and Haemophilus influenzae. A deep rough mutant of S typhimurium was more susceptible and accumulated the drug faster, and F porin deficient mutants of E coli were more resistant than parental strains. Trospectomycin likely uses both porin and nonporin pathways to cross the outer membrane. An E coli strain effectively accumulated the drug anaerobically, explaining its anaerobic activity. An H influenzae strain accumulated trospectomycin at concentrations below those for which detectable uptake could be observed with E coli or S typhimurium strains, consistent with greater activity in Haemophilus species.
dc.description.versionPeer Reviewed
dc.identifier.citationS Wong and LE Bryan, “Accumulation of Trospectomycin by Strains of Salmonella typhimurium, escherichia coli and Haemophilus influenzae,” Canadian Journal of Infectious Diseases, vol. 1, no. 2, pp. 51-56, 1990. doi:10.1155/1990/258273
dc.identifier.doihttps://doi.org/10.1155/1990/258273
dc.identifier.urihttp://hdl.handle.net/1880/108665
dc.identifier.urihttps://doi.org/10.11575/PRISM/44891
dc.language.rfc3066en
dc.rights.holderCopyright © 1990 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleAccumulation of Trospectomycin by Strains of Salmonella typhimurium, escherichia coli and Haemophilus influenzae
dc.typeJournal Article
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