Small organic molecule disruptors of Cav3.2 - USP5 interactions reverse inflammatory and neuropathic pain

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dc.contributor.authorGadotti, Vinícius Maria
dc.contributor.authorCaballero, Agustin Garcia
dc.contributor.authorBerger, N. Daniel
dc.contributor.authorGladding, Clare M.
dc.contributor.authorChen, Lina
dc.contributor.authorPfeifer, Tom A.
dc.contributor.authorZamponi, Gerald W.
dc.date.accessioned2018-06-06T19:10:25Z
dc.date.available2018-06-06T19:10:25Z
dc.date.issued2015-12
dc.description.abstractCav3.2 channels facilitate nociceptive transmission and are upregulated in DRG neurons in response to nerve injury or peripheral inflammation. We reported that this enhancement of Cav3.2 currents in afferent neurons is mediated by deubiquitination of the channels by the deubiquitinase USP5, and that disrupting USP5/Cav3.2 channel interactions protected from inflammatory and neuropathic pain.en_US
dc.identifier.citationGadotti, V. M., Caballero, A. G., Berger, N. D., Gladding, C. M., Chen, L., Pfeifer, T. A., & Zamponi, G. W. (2015). Small Organic Molecule Disruptors of Cav3.2 - USP5 Interactions Reverse Inflammatory and Neuropathic Pain. Molecular Pain, 11. https://doi.org/10.1186/s12990-015-0011-8en_US
dc.identifier.doihttp://dx.doi.org/10.1186/s12990-015-0011-8en_US
dc.identifier.issn1744-8069
dc.identifier.urihttp://hdl.handle.net/1880/106726
dc.language.isoenen_US
dc.publisherBioMed Central Ltd.en_US
dc.publisher.departmentPhysiology & Pharmacologyen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.publisher.policyhttp://www.sherpa.ac.uk/romeo/search.phpen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.subjectT-type channelsen_US
dc.subjectUSP5en_US
dc.subjectChronic painen_US
dc.subjectSuraminen_US
dc.subjectGossypetinen_US
dc.titleSmall organic molecule disruptors of Cav3.2 - USP5 interactions reverse inflammatory and neuropathic painen_US
dc.typejournal articleen_US
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