Full-term deliveries without antecedent labor reveal sex differences in umbilical cord glucocorticoid concentrations.

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dc.contributor.authorGiesbrecht, Gerald
dc.contributor.authorRash, Joshua, A.
dc.contributor.authorEdwards, Heather, E.
dc.contributor.authorWynne-Edwards, Katherine, E.
dc.date.accessioned2016-12-01T21:29:36Z
dc.date.available2016-12-01T21:29:36Z
dc.date.issued2016-12
dc.descriptionAuthor's accepted manuscript deposited according to Elsevier sharing policies: http://www.elsevier.com/about/company-information/policies/policy-faq (December 1st, 2016)en_US
dc.description.abstractBackground: Previous studies have shown that pregnant women have higher salivary cortisol levels when the fetus is female. These findings suggest a basis for the sex differences observed in many offspring outcomes after exposure to in utero stress, but it is not known if fetal adrenal glucocorticoid synthesis differs by sex. Methods: Arterial and venous umbilical cord blood samples were collected immediately after scheduled cesarean delivery (n = 52, 25 female). Cortisol and corticosterone concentrations were quantified by liquid chromatography coupled to tandem mass spectrometry. Results: Sex differences were observed for fetal arterial and venous cortisol and venous corticosterone, with higher levels present when the fetus was female. However, sex differences were not observed for fetal synthesis of cortisol, suggesting that the fetus does not control the differences observed in cord blood glucocorticoids. Conclusions: The presence of sex differences in umbilical cord glucocorticoid concentrations in the absence of sex differences in glucocorticoid synthesis by the fetal adrenal gland suggests that these differences have a maternal or placental origin. Thus, the in utero glucocorticoids in circulation are sex-specific and may have developmental importance for sex differences in psychiatric and neurodevelopment disorders that display sex biases.en_US
dc.description.refereedYesen_US
dc.identifier.citationGiesbrecht, G.F., Rash, J.A., Edwards, H., Wynne-Edwards, K. (2016). Full-term deliveries without antecedent labor reveal sex differences in umbilical cord glucocorticoid concentrations. Psychoneuroendocrinology, 74 (December), 121-125.en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33633
dc.identifier.urihttp://hdl.handle.net/1880/51760
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.publisher.corporateUniversity of Calgary
dc.publisher.departmentPaediatricsen_US
dc.publisher.facultyMedicineen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.publisher.urlhttps://www.elsevier.com/en_US
dc.rightsAttribution Non-Commercial No Derivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCesarean deliveryen_US
dc.subjectCord blooden_US
dc.subjectCorticosteroneen_US
dc.subjectCortisolen_US
dc.subjectSex differencesen_US
dc.titleFull-term deliveries without antecedent labor reveal sex differences in umbilical cord glucocorticoid concentrations.en_US
dc.typejournal article
thesis.degree.disciplinePaediatrics
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