Both 50 and 30 Hz continuous theta burst transcranial magnetic stimulation depresses the cerebellum

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dc.contributor.authorStrzalkowski, Nicholas D. J.
dc.contributor.authorChau, Aaron D.
dc.contributor.authorGan, Liu Shi
dc.contributor.authorKiss, Zelma H. T.
dc.date.accessioned2018-11-07T15:42:44Z
dc.date.available2018-11-07T15:42:44Z
dc.date.issued2018-08-16
dc.description.abstractThe cerebellum is implicated in the pathophysiology of numerous movement disorders, which makes it an attractive target for non-invasive neurostimulation. Continuous theta burst stimulation (cTBS) can induce long-lasting plastic changes in human brain; however, the efficacy of different simulation protocols has not been investigated at the cerebellum. Here, we compare a traditional 50-Hz and a modified 30-Hz cTBS protocols at modulating cerebellar activity in healthy subjects. Seventeen healthy adults participated in two testing sessions where they received either 50-Hz (cTBS50) or 30-Hz (cTBS30) cerebellar cTBS. Cerebellar brain inhibition (CBI), a measure of cerebello-thalamocortical pathway strength, and motor-evoked potentials (MEP) were measured in the dominant first dorsal interosseous muscle before and after (up to ~ 40 min) cerebellar cTBS. Both cTBS protocols induced cerebellar depression, indicated by significant reductions in CBI (P < 0.001). No differences were found between protocols (cTBS50 and cTBS30) at any time point (P = 0.983). MEP amplitudes were not significantly different following either cTBS protocol (P = 0.130). The findings show cerebellar excitability to be equally depressed by 50-Hz and 30-Hz cTBS in healthy adults and support future work to explore the efficacy of different cerebellar cTBS protocols in movement disorder patients where cerebellar depression could provide therapeutic benefits.en_US
dc.identifier.citationStrzalkowski, N. D. J., Chau, A. D., Gan, L. S., & Kiss, Z. H. T. (2018). Both 50 and 30 Hz continuous theta burst transcranial magnetic stimulation depresses the cerebellum. http://dx.doi.org/10.1007/s12311-018-0971-0.en_US
dc.identifier.doihttp://dx.doi.org/10.1007/s12311-018-0971-0en_US
dc.identifier.urihttp://hdl.handle.net/1880/108958
dc.language.isoenen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.titleBoth 50 and 30 Hz continuous theta burst transcranial magnetic stimulation depresses the cerebellumen_US
dc.typeunknown
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