Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits

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dc.contributor.authorPiƱa-Crespo, Juan C.
dc.contributor.authorTalantova, Maria V.
dc.contributor.authorMicu, Ileana
dc.contributor.authorStates, Bradley A.
dc.contributor.authorChen, Huei Sheng Vincent
dc.contributor.authorTu, Shichun
dc.contributor.authorNakanishi, Nobuki
dc.contributor.authorTong, Gary G.
dc.contributor.authorZhang, Dongxian
dc.contributor.authorHeinemann, Stephen F.
dc.contributor.authorZamponi, Gerald W.
dc.contributor.authorStys, Peter K.
dc.contributor.authorLipton, Stuart A.
dc.date.accessioned2018-05-24T15:08:49Z
dc.date.available2018-05-24T15:08:49Z
dc.date.issued2010-08-25
dc.description.abstractNMDA receptors are typically excited by a combination of glutamate and glycine. Here we describe excitatory responses in CNS myelin that are gated by a glycine agonist alone and mediated by NR1/NR3 "NMDA" receptor subunits. Response properties include activation by d-serine, inhibition by the glycine-site antagonist CNQX, and insensitivity to the glutamate-site antagonist d-APV. d-Serine responses were abrogated in NR3A-deficient mice. Our results suggest the presence of functional NR1/NR3 receptors in CNS myelin.en_US
dc.identifier.citationPina-Crespo, J. C., Talantova, M., Micu, I., States, B., Chen, H. S., Tu, S., . . . Lipton, S. A. (2010). Excitatory Glycine Responses of CNS Myelin Mediated by NR1/NR3 "NMDA" Receptor Subunits. Journal of Neuroscience, 30(34), 11501-11505. doi:10.1523/jneurosci.1593-10.2010en_US
dc.identifier.doihttp://dx.doi.org/10.1523/JNEUROSCI.1593-10.2010en_US
dc.identifier.urihttp://hdl.handle.net/1880/106659
dc.language.isoenen_US
dc.publisherSociety for Neuroscienceen_US
dc.publisher.departmentPhysiology & Pharmacologyen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.titleExcitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunitsen_US
dc.typeunknown
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