Mesenchymal Stromal/Stem Cells in Regenerative Medicine and Tissue Engineering

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dc.contributor.authorFitzsimmons, Ross E. B.
dc.contributor.authorMazurek, Matthew S.
dc.contributor.authorSoos, Agnes
dc.contributor.authorSimmons, Craig A.
dc.date.accessioned2018-09-26T07:28:19Z
dc.date.available2018-09-26T07:28:19Z
dc.date.issued2018-08-19
dc.date.updated2018-09-26T07:28:18Z
dc.description.abstractAs a result of over five decades of investigation, mesenchymal stromal/stem cells (MSCs) have emerged as a versatile and frequently utilized cell source in the fields of regenerative medicine and tissue engineering. In this review, we summarize the history of MSC research from the initial discovery of their multipotency to the more recent recognition of their perivascular identity in vivo and their extraordinary capacity for immunomodulation and angiogenic signaling. As well, we discuss long-standing questions regarding their developmental origins and their capacity for differentiation toward a range of cell lineages. We also highlight important considerations and potential risks involved with their isolation, ex vivo expansion, and clinical use. Overall, this review aims to serve as an overview of the breadth of research that has demonstrated the utility of MSCs in a wide range of clinical contexts and continues to unravel the mechanisms by which these cells exert their therapeutic effects.
dc.description.versionPeer Reviewed
dc.identifier.citationRoss E. B. Fitzsimmons, Matthew S. Mazurek, Agnes Soos, and Craig A. Simmons, “Mesenchymal Stromal/Stem Cells in Regenerative Medicine and Tissue Engineering,” Stem Cells International, vol. 2018, Article ID 8031718, 16 pages, 2018. doi:10.1155/2018/8031718
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/32982
dc.identifier.urihttp://dx.doi.org/10.1155/2018/8031718
dc.identifier.urihttp://hdl.handle.net/1880/107819
dc.language.rfc3066en
dc.rights.holderCopyright © 2018 Ross E. B. Fitzsimmons et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleMesenchymal Stromal/Stem Cells in Regenerative Medicine and Tissue Engineering
dc.typeJournal Article
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