Association between SMOFlipid and impaired brain development on term-equivalent age brain magnetic resonance imaging in very preterm infants

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dc.contributor.authorAl-Mouqdad, Mountasser M.
dc.contributor.authorAlshaikh, Belal
dc.contributor.authorSumaily, Haider H.
dc.contributor.authorAlodhaidan, Nabeel A.
dc.contributor.authorAlMahmoud, Latifah
dc.contributor.authorAlmotiri, Ameen A.
dc.contributor.authorAlkhourmi, Mousa A.
dc.contributor.authorAbounassif, Mazen M.
dc.contributor.authorBeh, Ahmed F.
dc.contributor.authorAlawad, Mashael A.
dc.contributor.authorAlbraiki, Amani A.
dc.contributor.authorAlqarni, Aziza A.
dc.contributor.authorAl-Anazi, Maha R.
dc.contributor.authorBasodan, Nadia A.
dc.contributor.authorAssiri, Fuddah M.
dc.contributor.authorAsfour, Suzan S.
dc.date.accessioned2024-11-03T01:04:28Z
dc.date.available2024-11-03T01:04:28Z
dc.date.issued2024-10-29
dc.date.updated2024-11-03T01:04:28Z
dc.description.abstractAbstract Soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOFlipid) is used without evidence of benefits. We investigated the relationship between lipid emulsions and brain injury in term-equivalent age magnetic resonance imaging (MRI) in 148 very preterm infants with a birth weight of < 1500 g at ≤ 32 gestational weeks in a neonatal intensive care unit. Infants who received soybean-based lipid emulsions between January 2015 and December 2018 were compared with those who received SMOFlipids between January 2019 and December 2022. A negative binomial generalized linear model was applied for bivariate analysis. Modified log-Poisson regression with generalized linear models and a robust variance estimator (Huber–White) were applied to adjust for potential confounders. The Kidokoro score was used to determine if lipid emulsion type would affect brain morphology and growth at term-equivalent age. Eighty-six (58.9%) received SMOFlipid. SMOFlipid was associated with lower focal signal abnormality, myelination delay, increased extracerebral space, and cerebellar volume reduction (P = 0.02, P = 0.007, P = 0.01, P = 0.02, respectively). SMOFlipidis are associated with brain insult, especially in white matter, cortical gray matter, and the cerebellum. Well-designed studies are needed to investigate the effect of lipid emulsions on the central nervous system.
dc.identifier.citationBMC Pediatrics. 2024 Oct 29;24(1):686
dc.identifier.urihttps://doi.org/10.1186/s12887-024-05153-8
dc.identifier.urihttps://hdl.handle.net/1880/120038
dc.language.rfc3066en
dc.rights.holderThe Author(s)
dc.titleAssociation between SMOFlipid and impaired brain development on term-equivalent age brain magnetic resonance imaging in very preterm infants
dc.typeJournal Article
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