Prenatal bisphenol a exposure and dysregulation of infant hypothalamic-pituitary-adrenal axis function: findings from the APrON cohort study

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dc.contributor.authorGiesbrecht, G. F.
dc.contributor.authorEjaredar, Maede
dc.contributor.authorLiu, Jiaying
dc.contributor.authorThomas, Jenna C.
dc.contributor.authorLetourneau, Nicole Lyn
dc.contributor.authorCampbell, Tavis S.
dc.contributor.authorMartin, Jonathan W.
dc.contributor.authorDewey, Deborah
dc.contributor.authorAPrON Study Team
dc.date.accessioned2018-12-03T19:43:29Z
dc.date.available2018-12-03T19:43:29Z
dc.date.issued2017-05-19
dc.description.abstractBackground: Animal models show that prenatal bisphenol A (BPA) exposure leads to sexually-dimorphic disruption of the neuroendocrine system in offspring, including the hypothalamic-pituitary-adrenal (HPA) neuroendocrine system, but human data are lacking. In humans, prenatal BPA exposure is associated with sex-specific behavioural problems in children, and HPA axis dysregulation may be a biological mechanism. The objective of the current study was to examine sex differences in associations between prenatal maternal urinary BPA concentration and HPA axis function in 3-month-old infants. Methods: Mother-infant pairs (n = 132) were part of the Alberta Pregnancy Outcomes and Nutrition study, a longitudinal birth cohort recruited (2010–2012) during pregnancy. Maternal spot urine samples collected during the 2nd trimester were analyzed for total BPA and creatinine. Infant saliva samples collected prior to and after a blood draw were analyzed for cortisol. Linear growth curve models were used to characterize changes in infant cortisol as a function of prenatal BPA exposure. Results: Higher maternal BPA was associated with increases in baseline cortisol among females (β = 0.13 log μg/dL; 95% CI: 0.01, 0.26), but decreases among males (β = −0.22 log μg/dL; 95% CI: -0.39, −0.05). In contrast, higher BPA was associated with increased reactivity in males (β = .30 log μg/dL; 95% CI: 0.04, 0.56) but decreased reactivity in females (β = −0.15 log μg/dL; 95% CI: -0.35, 0.05). Models adjusting for creatinine yielded similar results. Conclusions: Prenatal BPA exposure is associated with sex-specific changes in infant HPA axis function. The biological plausibility of these findings is supported by their consistency with evidence in rodent models. Furthermore, these data support the hypotheses that sexually dimorphic changes in children’s behaviour following prenatal BPA exposure are mediated by sexually-dimorphic changes in HPA axis function. Keywords: Bisphenol-A, Fetal exposure, Cortisol, Hypothalamic-pituitary-adrenal axis, Infant stress reactivityen_US
dc.description.grantingagencyCanadian Institutes of Health Research - Other Programsen_US
dc.description.grantingagencyAlberta Health Services - Research Granten_US
dc.description.sponsorshipSponsored by the Open Access Authors Funden_US
dc.identifier.citationGiesbrecht, G. F., Ejaredar, M., Liu, J., Thomas, J. C., Letourneau, N. L., Campbell, T. S., … Team, S. (2017). Prenatal bisphenol a exposure and dysregulation of infant hypothalamic- pituitary-adrenal axis function : findings from the APrON cohort study. "Environmental Health", 16:47, 1–11. https://doi.org/10.1186/s12940-017-0259-8en_US
dc.identifier.doihttp://dx.doi.org/10.1186/s12940-017-0259-8en_US
dc.identifier.grantnumberMOP-106593, MOP-123535, 100415TOPen_US
dc.identifier.urihttp://hdl.handle.net/1880/109221
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.publisher.departmentPaediatricsen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.hasversionPublisher's versionen_US
dc.publisher.policyhttps://ehjournal.biomedcentral.com/abouten_US
dc.relation.ispartofseries16:47en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.subjectBisphenol-Aen_US
dc.subjectFetal exposureen_US
dc.subjectCortisolen_US
dc.subjectHypothalamic-pituitary-adrenal axisen_US
dc.subjectInfant stress reactivityen_US
dc.titlePrenatal bisphenol a exposure and dysregulation of infant hypothalamic-pituitary-adrenal axis function: findings from the APrON cohort studyen_US
dc.typejournal articleen_US
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