Voxel Placement Precision for GABA-Edited Magnetic Resonance Spectroscopy
Date
2017-01-01
Journal Title
Journal ISSN
Volume Title
Publisher
Scientific Research Publishing, Inc.
Abstract
The purpose of the present study was to assess the reproducibility of voxel placement for GABA-edited MRS. GABA-edited MRS data were acquired in 13 healthy volunteers from (3 cm)3 voxel; and within the same session a second acquisition was independently prescribed. A three-dimensional voxel mask image was reconstructed in T1-image-space using the SVMask tool (in house software). Reproducibility of voxel placement was assessed using the Dice overlap coefficient, both within-subject and between-subject following co-registration of T1 images and transformation of voxel mask images to standard space. Within-subject overlap coefficients were 86% ± 5%. Between-subject overlap coefficients were 75% ± 10%. For the two voxel locations considered (occipital and sensorimotor), voxel overlap was very similar. Between-subject values are higher due to between-session effects, anatomical variability and volume mismatch in standard space. While surprisingly low in terms of volume overlap, the overlap coefficients correspond to acceptable linear displacements.
Description
Keywords
MRS, Voxel placement, precision, Voxel prescription, registration
Citation
Bai, X., D. Harris, A., Gong, T., A. J. Puts, N., Wang, G., Schär, M., B. Barker, P., & A. E. Edden, R. (2017). Voxel Placement Precision for GABA-Edited Magnetic Resonance Spectroscopy. Open Journal of Radiology, 07(01), 35–44. https://doi.org/10.4236/ojrad.2017.71004