The ChoCO-W prospective observational global study: Does COVID-19 increase gangrenous cholecystitis?

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dc.contributor.authorDe Simone, Belinda
dc.contributor.authorAbu-Zidan, Fikri M.
dc.contributor.authorChouillard, Elie
dc.contributor.authorDi Saverio, Salomone
dc.contributor.authorSartelli, Massimo
dc.contributor.authorPodda, Mauro
dc.contributor.authorGomes, Carlos A.
dc.contributor.authorMoore, Ernest E.
dc.contributor.authorMoug, Susan J.
dc.contributor.authorAnsaloni, Luca
dc.contributor.authorKluger, Yoram
dc.contributor.authorCoccolini, Federico
dc.contributor.authorLandaluce-Olavarria, Aitor
dc.contributor.authorEstraviz-Mateos, Begoña
dc.contributor.authorUriguen-Etxeberria, Ana
dc.contributor.authorGiordano, Alessio
dc.contributor.authorLuna, Alfonso P.
dc.contributor.authorAmín, Luz A. H.
dc.contributor.authorHernández, Adriana M. P.
dc.contributor.authorShabana, Amanda
dc.contributor.authorDzulkarnaen, Zakaria A.
dc.contributor.authorOthman, Muhammad A.
dc.contributor.authorSani, Mohamad I.
dc.contributor.authorBalla, Andrea
dc.contributor.authorScaramuzzo, Rosa
dc.contributor.authorLepiane, Pasquale
dc.contributor.authorBottari, Andrea
dc.contributor.authorStaderini, Fabio
dc.contributor.authorCianchi, Fabio
dc.contributor.authorCavallaro, Andrea
dc.contributor.authorZanghì, Antonio
dc.contributor.authorCappellani, Alessandro
dc.contributor.authorCampagnacci, Roberto
dc.contributor.authorMaurizi, Angela
dc.contributor.authorMartinotti, Mario
dc.contributor.authorRuggieri, Annamaria
dc.contributor.authorJusoh, Asri C.
dc.contributor.authorRahman, Karim A.
dc.contributor.authorZulkifli, Anis S. M.
dc.contributor.authorPetronio, Barbara
dc.contributor.authorMatías-García, Belén
dc.contributor.authorQuiroga-Valcárcel, Ana
dc.contributor.authorMendoza-Moreno, Fernando
dc.contributor.authorAtanasov, Boyko
dc.contributor.authorCampanile, Fabio C.
dc.contributor.authorVecchioni, Ilaria
dc.contributor.authorCardinali, Luca
dc.contributor.authorTravaglini, Grazia
dc.contributor.authorSebastiani, Elisa
dc.contributor.authorChooklin, Serge
dc.contributor.authorChuklin, Serhii
dc.contributor.authorCianci, Pasquale
dc.contributor.authorRestini, Enrico
dc.contributor.authorCapuzzolo, Sabino
dc.contributor.authorCurrò, Giuseppe
dc.contributor.authorFilippo, Rosalinda
dc.contributor.authorRispoli, Michele
dc.contributor.authorAparicio-Sánchez, Daniel
dc.contributor.authorMuñóz-Cruzado, Virginia D.
dc.contributor.authorBarbeito, Sandra D.
dc.contributor.authorDelibegovic, Samir
dc.contributor.authorKesetovic, Amar
dc.contributor.authorSasia, Diego
dc.contributor.authorBorghi, Felice
dc.contributor.authorGiraudo, Giorgio
dc.contributor.authorVisconti, Diego
dc.contributor.authorDoria, Emanuele
dc.contributor.authorSantarelli, Mauro
dc.contributor.authorLuppi, Davide
dc.contributor.authorBonilauri, Stefano
dc.contributor.authorGrossi, Ugo
dc.contributor.authorZanus, Giacomo
dc.contributor.authorSartori, Alberto
dc.contributor.authorPiatto, Giacomo
dc.contributor.authorDe Luca, Maurizio
dc.contributor.authorVita, Domenico
dc.contributor.authorConti, Luigi
dc.contributor.authorCapelli, Patrizio
dc.contributor.authorCattaneo, Gaetano M.
dc.contributor.authorMarinis, Athanasios
dc.contributor.authorVederaki, Styliani-Aikaterini
dc.contributor.authorBayrak, Mehmet
dc.contributor.authorAltıntas, Yasemin
dc.contributor.authorUzunoglu, Mustafa Y.
dc.contributor.authorDemirbas, Iskender E.
dc.contributor.authorAltinel, Yuksel
dc.contributor.authorMeric, Serhat
dc.contributor.authorAktimur, Yunus E.
dc.contributor.authorUymaz, Derya S.
dc.contributor.authorOmarov, Nail
dc.contributor.authorAzamat, Ibrahim
dc.contributor.authorLostoridis, Eftychios
dc.contributor.authorNagorni, Eleni-Aikaterini
dc.contributor.authorPujante, Antonio
dc.contributor.authorAnania, Gabriele
dc.contributor.authorBombardini, Cristina
dc.contributor.authorBagolini, Francesco
dc.contributor.authorGonullu, Emre
dc.contributor.authorMantoglu, Baris
dc.contributor.authorCapoglu, Recayi
dc.contributor.authorCappato, Stefano
dc.contributor.authorMuzio, Elena
dc.contributor.authorColak, Elif
dc.contributor.authorPolat, Suleyman
dc.contributor.authorKoylu, Zehra A.
dc.contributor.authorAltintoprak, Fatih
dc.contributor.authorBayhan, Zülfü
dc.contributor.authorAkin, Emrah
dc.contributor.authorAndolfi, Enrico
dc.contributor.authorRezart, Sulce
dc.contributor.authorKim, Jae I.
dc.contributor.authorJung, Sung W.
dc.contributor.authorShin, Yong C.
dc.contributor.authorEnciu, Octavian
dc.contributor.authorToma, Elena A.
dc.contributor.authorMedas, Fabio
dc.contributor.authorCanu, Gian L.
dc.contributor.authorCappellacci, Federico
dc.contributor.authorD’Acapito, Fabrizio
dc.contributor.authorErcolani, Giorgio
dc.contributor.authorSolaini, Leonardo
dc.contributor.authorRoscio, Francesco
dc.contributor.authorClerici, Federico
dc.contributor.authorGelmini, Roberta
dc.contributor.authorSerra, Francesco
dc.contributor.authorRossi, Elena G.
dc.contributor.authorFleres, Francesco
dc.contributor.authorClarizia, Guglielmo
dc.contributor.authorSpolini, Alessandro
dc.contributor.authorFerrara, Francesco
dc.contributor.authorNita, Gabriela
dc.contributor.authorSarnari, Jlenia
dc.contributor.authorGachabayov, Mahir
dc.contributor.authorAbdullaev, Abakar
dc.contributor.authorPoillucci, Gaetano
dc.contributor.authorPalini, Gian M.
dc.contributor.authorVeneroni, Simone
dc.contributor.authorGarulli, Gianluca
dc.contributor.authorPiccoli, Micaela
dc.contributor.authorPattacini, Gianmaria C.
dc.contributor.authorPecchini, Francesca
dc.contributor.authorArgenio, Giulio
dc.contributor.authorArmellino, Mariano F.
dc.contributor.authorBrisinda, Giuseppe
dc.contributor.authorTedesco, Silvia
dc.contributor.authorFransvea, Pietro
dc.contributor.authorIetto, Giuseppe
dc.contributor.authorFranchi, Caterina
dc.contributor.authorCarcano, Giulio
dc.contributor.authorMartines, Gennaro
dc.contributor.authorTrigiante, Giuseppe
dc.contributor.authorNegro, Giulia
dc.contributor.authorVega, Gustavo M.
dc.contributor.authorGonzález, Agustín R.
dc.contributor.authorOjeda, Leonardo
dc.contributor.authorPiccolo, Gaetano
dc.contributor.authorBondurri, Andrea
dc.contributor.authorMaffioli, Anna
dc.contributor.authorGuerci, Claudio
dc.contributor.authorSin, Boo H.
dc.contributor.authorZuhdi, Zamri
dc.contributor.authorAzman, Azlanudin
dc.contributor.authorMousa, Hussam
dc.contributor.authoral Bahri, Shadi
dc.contributor.authorAugustin, Goran
dc.contributor.authorRomic, Ivan
dc.contributor.authorMoric, Trpimir
dc.contributor.authorNikolopoulos, Ioannis
dc.contributor.authorAndreuccetti, Jacopo
dc.contributor.authorPignata, Giusto
dc.contributor.authorD’Alessio, Rossella
dc.contributor.authorKenig, Jakub
dc.contributor.authorSkorus, Urszula
dc.contributor.authorFraga, Gustavo P.
dc.contributor.authorHirano, Elcio S.
dc.contributor.authorde Lima Bertuol, Jackson V.
dc.contributor.authorIsik, Arda
dc.contributor.authorKurnaz, Eray
dc.contributor.authorAsghar, Mohammad S.
dc.contributor.authorAfzal, Ameer
dc.contributor.authorAkbar, Ali
dc.contributor.authorNikolouzakis, Taxiarchis K.
dc.contributor.authorLasithiotakis, Konstantinos
dc.contributor.authorChrysos, Emmanuel
dc.contributor.authorDas, Koray
dc.contributor.authorÖzer, Nazmi
dc.contributor.authorSeker, Ahmet
dc.contributor.authorIbrahim, Mohamed
dc.contributor.authorHamid, Hytham K. S.
dc.contributor.authorBabiker, Ahmed
dc.contributor.authorBouliaris, Konstantinos
dc.contributor.authorKoukoulis, George
dc.contributor.authorKolla, Chrysoula-Christina
dc.contributor.authorLucchi, Andrea
dc.contributor.authorAgostinelli, Laura
dc.contributor.authorTaddei, Antonio
dc.contributor.authorFortuna, Laura
dc.contributor.authorAgostini, Carlotta
dc.contributor.authorLicari, Leo
dc.contributor.authorViola, Simona
dc.contributor.authorCallari, Cosimo
dc.contributor.authorLaface, Letizia
dc.contributor.authorAbate, Emmanuele
dc.contributor.authorCasati, Massimiliano
dc.contributor.authorAnastasi, Alessandro
dc.contributor.authorCanonico, Giuseppe
dc.contributor.authorGabellini, Linda
dc.contributor.authorTosi, Lorenzo
dc.contributor.authorGuariniello, Anna
dc.contributor.authorZanzi, Federico
dc.contributor.authorBains, Lovenish
dc.contributor.authorSydorchuk, Larysa
dc.contributor.authorIftoda, Oksana
dc.contributor.authorSydorchuk, Andrii
dc.contributor.authorMalerba, Michele
dc.contributor.authorCostanzo, Federico
dc.contributor.authorGalleano, Raffaele
dc.contributor.authorMonteleone, Michela
dc.contributor.authorCostanzi, Andrea
dc.contributor.authorRiva, Carlo
dc.contributor.authorWalędziak, Maciej
dc.contributor.authorKwiatkowski, Andrzej
dc.contributor.authorCzyżykowski, Łukasz
dc.contributor.authorMajor, Piotr
dc.contributor.authorStrzałka, Marcin
dc.contributor.authorMatyja, Maciej
dc.contributor.authorNatkaniec, Michal
dc.contributor.authorValenti, Maria R.
dc.contributor.authorDi Vita, Maria D. P.
dc.contributor.authorSotiropoulou, Maria
dc.contributor.authorKapiris, Stylianos
dc.contributor.authorMassalou, Damien
dc.contributor.authorVeroux, Massimiliano
dc.contributor.authorVolpicelli, Alessio
dc.contributor.authorGioco, Rossella
dc.contributor.authorUccelli, Matteo
dc.contributor.authorBonaldi, Marta
dc.contributor.authorOlmi, Stefano
dc.contributor.authorNardi, Matteo
dc.contributor.authorLivadoti, Giada
dc.contributor.authorMesina, Cristian
dc.contributor.authorDumitrescu, Theodor V.
dc.contributor.authorCiorbagiu, Mihai C.
dc.contributor.authorAmmendola, Michele
dc.contributor.authorAmmerata, Giorgio
dc.contributor.authorRomano, Roberto
dc.contributor.authorSlavchev, Mihail
dc.contributor.authorMisiakos, Evangelos P.
dc.contributor.authorPikoulis, Emmanouil
dc.contributor.authorPapaconstantinou, Dimitrios
dc.contributor.authorElbahnasawy, Mohamed
dc.contributor.authorAbdel-elsalam, Sherief
dc.contributor.authorFelsenreich, Daniel M.
dc.contributor.authorJedamzik, Julia
dc.contributor.authorMichalopoulos, Nikolaos V.
dc.contributor.authorSidiropoulos, Theodoros A.
dc.contributor.authorPapadoliopoulou, Maria
dc.contributor.authorCillara, Nicola
dc.contributor.authorDeserra, Antonello
dc.contributor.authorCannavera, Alessandro
dc.contributor.authorNegoi, Ionuţ
dc.contributor.authorSchizas, Dimitrios
dc.contributor.authorSyllaios, Athanasios
dc.contributor.authorVagios, Ilias
dc.contributor.authorGourgiotis, Stavros
dc.contributor.authorDai, Nick
dc.contributor.authorGurung, Rekha
dc.contributor.authorNorrey, Marcus
dc.contributor.authorPesce, Antonio
dc.contributor.authorFeo, Carlo V.
dc.contributor.authorFabbri, Nicolo’
dc.contributor.authorMachairas, Nikolaos
dc.contributor.authorDorovinis, Panagiotis
dc.contributor.authorKeramida, Myrto D.
dc.contributor.authorMulita, Francesk
dc.contributor.authorVerras, Georgios I.
dc.contributor.authorVailas, Michail
dc.contributor.authorYalkin, Omer
dc.contributor.authorIflazoglu, Nidal
dc.contributor.authorYigit, Direnc
dc.contributor.authorBaraket, Oussama
dc.contributor.authorAyed, Karim
dc.contributor.authorGhalloussi, Mohamed h.
dc.contributor.authorPatias, Parmenion
dc.contributor.authorNtokos, Georgios
dc.contributor.authorRahim, Razrim
dc.contributor.authorBala, Miklosh
dc.contributor.authorKedar, Asaf
dc.contributor.authorSawyer, Robert G.
dc.contributor.authorTrinh, Anna
dc.contributor.authorMiller, Kelsey
dc.contributor.authorSydorchuk, Ruslan
dc.contributor.authorKnut, Ruslan
dc.contributor.authorPlehutsa, Oleksandr
dc.contributor.authorLiman, Rumeysa K.
dc.contributor.authorOzkan, Zeynep
dc.contributor.authorKader, Saleh A.
dc.contributor.authorGupta, Sanjay
dc.contributor.authorGureh, Monika
dc.contributor.authorSaeidi, Sara
dc.contributor.authorAliakbarian, Mohsen
dc.contributor.authorDalili, Amin
dc.contributor.authorShoko, Tomohisa
dc.contributor.authorKojima, Mitsuaki
dc.contributor.authorNakamoto, Raira
dc.contributor.authorAtici, Semra D.
dc.contributor.authorTuncer, Gizem K.
dc.contributor.authorKaya, Tayfun
dc.contributor.authorDelis, Spiros G.
dc.contributor.authorRossi, Stefano
dc.contributor.authorPicardi, Biagio
dc.contributor.authordel Monte, Simone R.
dc.contributor.authorTriantafyllou, Tania
dc.contributor.authorTheodorou, Dimitrios
dc.contributor.authorPintar, Tadeja
dc.contributor.authorSalobir, Jure
dc.contributor.authorManatakis, Dimitrios K.
dc.contributor.authorTasis, Nikolaos
dc.contributor.authorAcheimastos, Vasileios
dc.contributor.authorIoannidis, Orestis
dc.contributor.authorLoutzidou, Lydia
dc.contributor.authorSymeonidis, Savvas
dc.contributor.authorde Sá, Tiago C.
dc.contributor.authorRocha, Mónica
dc.contributor.authorGuagni, Tommaso
dc.contributor.authorPantalone, Desiré
dc.contributor.authorMaltinti, Gherardo
dc.contributor.authorKhokha, Vladimir
dc.contributor.authorAbdel-elsalam, Wafaa
dc.contributor.authorGhoneim, Basma
dc.contributor.authorLópez-Ruiz, José A.
dc.contributor.authorKara, Yasin
dc.contributor.authorZainudin, Syaza
dc.contributor.authorHayati, Firdaus
dc.contributor.authorAzizan, Nornazirah
dc.contributor.authorKhei, Victoria T. P.
dc.contributor.authorYi, Rebecca C. X.
dc.contributor.authorSellappan, Harivinthan
dc.contributor.authorDemetrashvili, Zaza
dc.contributor.authorLekiashvili, Nika
dc.contributor.authorTvaladze, Ana
dc.contributor.authorFroiio, Caterina
dc.contributor.authorBernardi, Daniele
dc.contributor.authorBonavina, Luigi
dc.contributor.authorGil-Olarte, Angeles
dc.contributor.authorGrassia, Sebastiano
dc.contributor.authorRomero-Vargas, Estela
dc.contributor.authorBianco, Francesco
dc.contributor.authorGumbs, Andrew A.
dc.contributor.authorDogjani, Agron
dc.contributor.authorAgresta, Ferdinando
dc.contributor.authorLitvin, Andrey
dc.contributor.authorBalogh, Zsolt J.
dc.contributor.authorGendrikson, George
dc.contributor.authorMartino, Costanza
dc.contributor.authorDamaskos, Dimitrios
dc.contributor.authorPararas, Nikolaos
dc.contributor.authorKirkpatrick, Andrew
dc.contributor.authorKurtenkov, Mikhail
dc.contributor.authorGomes, Felipe C.
dc.contributor.authorPisanu, Adolfo
dc.contributor.authorNardello, Oreste
dc.contributor.authorGambarini, Fabrizio
dc.contributor.authorAref, Hager
dc.contributor.authorAngelis, Nicola d.
dc.contributor.authorAgnoletti, Vanni
dc.contributor.authorBiondi, Antonio
dc.contributor.authorVacante, Marco
dc.contributor.authorGriggio, Giulia
dc.contributor.authorTutino, Roberta
dc.contributor.authorMassani, Marco
dc.contributor.authorBisetto, Giovanni
dc.contributor.authorOcchionorelli, Savino
dc.contributor.authorAndreotti, Dario
dc.contributor.authorLacavalla, Domenico
dc.contributor.authorBiffl, Walter L.
dc.contributor.authorCatena, Fausto
dc.date.accessioned2022-12-18T01:02:29Z
dc.date.available2022-12-18T01:02:29Z
dc.date.issued2022-12-16
dc.date.updated2022-12-18T01:02:29Z
dc.description.abstractAbstract Background The incidence of the highly morbid and potentially lethal gangrenous cholecystitis was reportedly increased during the COVID-19 pandemic. The aim of the ChoCO-W study was to compare the clinical findings and outcomes of acute cholecystitis in patients who had COVID-19 disease with those who did not. Methods Data were prospectively collected over 6 months (October 1, 2020, to April 30, 2021) with 1-month follow-up. In October 2020, Delta variant of SARS CoV-2 was isolated for the first time. Demographic and clinical data were analyzed and reported according to the STROBE guidelines. Baseline characteristics and clinical outcomes of patients who had COVID-19 were compared with those who did not. Results A total of 2893 patients, from 42 countries, 218 centers, involved, with a median age of 61.3 (SD: 17.39) years were prospectively enrolled in this study; 1481 (51%) patients were males. One hundred and eighty (6.9%) patients were COVID-19 positive, while 2412 (93.1%) were negative. Concomitant preexisting diseases including cardiovascular diseases (p < 0.0001), diabetes (p < 0.0001), and severe chronic obstructive airway disease (p = 0.005) were significantly more frequent in the COVID-19 group. Markers of sepsis severity including ARDS (p < 0.0001), PIPAS score (p < 0.0001), WSES sepsis score (p < 0.0001), qSOFA (p < 0.0001), and Tokyo classification of severity of acute cholecystitis (p < 0.0001) were significantly higher in the COVID-19 group. The COVID-19 group had significantly higher postoperative complications (32.2% compared with 11.7%, p < 0.0001), longer mean hospital stay (13.21 compared with 6.51 days, p < 0.0001), and mortality rate (13.4% compared with 1.7%, p < 0.0001). The incidence of gangrenous cholecystitis was doubled in the COVID-19 group (40.7% compared with 22.3%). The mean wall thickness of the gallbladder was significantly higher in the COVID-19 group [6.32 (SD: 2.44) mm compared with 5.4 (SD: 3.45) mm; p < 0.0001]. Conclusions The incidence of gangrenous cholecystitis is higher in COVID patients compared with non-COVID patients admitted to the emergency department with acute cholecystitis. Gangrenous cholecystitis in COVID patients is associated with high-grade Clavien-Dindo postoperative complications, longer hospital stay and higher mortality rate. The open cholecystectomy rate is higher in COVID compared with non -COVID patients. It is recommended to delay the surgical treatment in COVID patients, when it is possible, to decrease morbidity and mortality rates. COVID-19 infection and gangrenous cholecystistis are not absolute contraindications to perform laparoscopic cholecystectomy, in a case by case evaluation, in expert hands. Graphical abstract
dc.identifier.citationWorld Journal of Emergency Surgery. 2022 Dec 16;17(1):61
dc.identifier.doihttps://doi.org/10.1186/s13017-022-00466-4
dc.identifier.urihttp://hdl.handle.net/1880/115597
dc.identifier.urihttps://doi.org/10.11575/PRISM/45157
dc.language.rfc3066en
dc.rights.holderThe Author(s)
dc.titleThe ChoCO-W prospective observational global study: Does COVID-19 increase gangrenous cholecystitis?
dc.typeJournal Article
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