Efficacy of a Peruvian Botanical Remedy (Sabell A4+) for Treating Liver Disease and Protecting Gastric Mucosal Integrity

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dc.contributor.authorSwain, Mark G.
dc.contributor.authorWallace, John L.
dc.contributor.authorTyrrell, D. Lorne
dc.contributor.authorCabanillas, José
dc.contributor.authorAung, Steven K. H.
dc.contributor.authorLiu, Hongqun
dc.contributor.authorFinnie-Carvalho, Lindsay
dc.contributor.authorShrestha, Grishma
dc.contributor.authorSemple, Hugh A.
dc.contributor.authorGreen, Francis H. Y.
dc.date.accessioned2019-12-23T13:26:00Z
dc.date.available2019-12-23T13:26:00Z
dc.date.issued2019-10-24
dc.date.updated2019-12-23T13:26:00Z
dc.description.abstractThe purpose of this study was to determine the efficacy of a Peruvian botanical formulation for treating disorders of hepatic function and gastric mucosal integrity. The formulation A4+ (Sabell Corporation) contains extracts of Curcuma longa rhizome, Cordia lutea flower, and Annona muricata leaf. Individually these plants have been used as traditional remedies for liver disease. We report the efficacy of A4+ and its components using a variety of in vitro and in vivo disease models. The methods used included tests for antioxidant, anti-inflammatory, and antiviral activity as well as mouse models of liver disease, including Concanavalin A-induced immune-mediated hepatitis and a bile duct ligation model for evaluating sickness behaviour associated with liver disease. Rat models were used to evaluate the gastric mucosal protective property of A4+ following indomethacin challenge and to evaluate its anti-inflammatory action in an “air pouch” model. In all tests, A4+ proved to be more effective than placebo. A4+ was antioxidant and anti-inflammatory and diminished Hepatitis C virus replication in vitro. In animal models, A4+ was shown to protect the liver from immune-mediated hepatitis, improve behavioural function in animals with late stage liver disease, and protect the rat gastric mucosa from ulceration following NSAID exposure. We conclude that A4+ ameliorated many aspects of liver injury, inhibited hepatitis C virus replication, and protected the gastric mucosa from NSAIDs. These varied beneficial properties appear to result from positive interactions between the three constituent herbs.
dc.description.versionPeer Reviewed
dc.identifier.citationMark G. Swain, John L. Wallace, D. Lorne Tyrrell, et al., “Efficacy of a Peruvian Botanical Remedy (Sabell A4+) for Treating Liver Disease and Protecting Gastric Mucosal Integrity,” Evidence-Based Complementary and Alternative Medicine, vol. 2019, Article ID 5486728, 11 pages, 2019. doi:10.1155/2019/5486728
dc.identifier.urihttp://dx.doi.org/10.1155/2019/5486728
dc.identifier.urihttp://hdl.handle.net/1880/111384
dc.identifier.urihttps://dx.doi.org/10.11575/PRISM/37370
dc.language.rfc3066en
dc.rights.holderCopyright © 2019 Mark G. Swain et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleEfficacy of a Peruvian Botanical Remedy (Sabell A4+) for Treating Liver Disease and Protecting Gastric Mucosal Integrity
dc.typeJournal Article
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