Investigation of the Pre-ictal State Using Near Infrared Spectroscopy and Functional Magnetic Resonance Imaging
Date
2014-01-29
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Abstract
The unpredictability of seizures impacts the quality of life of those with epilepsy. Previous studies have reported changes in cerebral hemodynamics prior to the onset of seizures, providing evidence of the existence of a pre-ictal state. In this thesis, near infrared spectroscopy (NIRS) and functional magnetic resonance imaging (fMRI) techniques were developed to characterize the variation in cerebral hemodynamics prior to seizures, in patients with focal epilepsy. The findings indicate that there are changes in cerebral hemodynamics within both hemispheres minutes prior to seizures. These results provide encouraging evidence that, with further technical improvements in the specificity of these techniques, the identification of such changes could allow sufficient time for measures to be taken to prevent seizure onset, thereby reducing the likelihood of seizures and improving the quality of life of those with epilepsy.
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Neuroscience
Citation
Vinette, S. (2014). Investigation of the Pre-ictal State Using Near Infrared Spectroscopy and Functional Magnetic Resonance Imaging (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26662