Investigation of the Pre-ictal State Using Near Infrared Spectroscopy and Functional Magnetic Resonance Imaging

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atmire.migration.oldid1899
dc.contributor.advisorFederico, Paolo
dc.contributor.authorVinette, Sarah
dc.date.accessioned2014-01-29T21:40:50Z
dc.date.available2014-03-15T07:00:20Z
dc.date.issued2014-01-29
dc.date.submitted2014en
dc.description.abstractThe unpredictability of seizures impacts the quality of life of those with epilepsy. Previous studies have reported changes in cerebral hemodynamics prior to the onset of seizures, providing evidence of the existence of a pre-ictal state. In this thesis, near infrared spectroscopy (NIRS) and functional magnetic resonance imaging (fMRI) techniques were developed to characterize the variation in cerebral hemodynamics prior to seizures, in patients with focal epilepsy. The findings indicate that there are changes in cerebral hemodynamics within both hemispheres minutes prior to seizures. These results provide encouraging evidence that, with further technical improvements in the specificity of these techniques, the identification of such changes could allow sufficient time for measures to be taken to prevent seizure onset, thereby reducing the likelihood of seizures and improving the quality of life of those with epilepsy.en_US
dc.identifier.citationVinette, S. (2014). Investigation of the Pre-ictal State Using Near Infrared Spectroscopy and Functional Magnetic Resonance Imaging (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26662en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/26662
dc.identifier.urihttp://hdl.handle.net/11023/1325
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectNeuroscience
dc.subject.classificationEpilepsyen_US
dc.subject.classificationSeizureen_US
dc.subject.classificationPre-ictalen_US
dc.subject.classificationfMRIen_US
dc.subject.classificationNIRSen_US
dc.titleInvestigation of the Pre-ictal State Using Near Infrared Spectroscopy and Functional Magnetic Resonance Imaging
dc.typemaster thesis
thesis.degree.disciplineNeuroscience
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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