In vivo Assessment of Human Brainstem Cerebrovascular Function: A Multi-Inversion Time Pulsed Arterial Spin Labelling Study

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dc.contributor.authorWarnert, Esther A.H.
dc.contributor.authorHarris, Ashley D.
dc.contributor.authorMurphy, Kevin
dc.contributor.authorSaxena, Neerja
dc.contributor.authorTailor, Neeta
dc.contributor.authorJenkins, Nigel S.
dc.contributor.authorHall, Judith E.
dc.contributor.authorWise, Richard G.
dc.date.accessioned2021-01-06T20:50:57Z
dc.date.available2021-01-06T20:50:57Z
dc.date.issued2014-03-05
dc.description.abstractThe brainstem (BS) is involved in critical physiologic processes, including control of cardiovascular and respiratory functions. This study implements a multi-inversion time pulsed arterial spin labelling (MTI PASL) imaging sequence that addresses the challenges of BS imaging and aims to measure normal and elevated BS perfusion in healthy volunteers. An initial experiment was performed to obtain the kinetic curve of the label in the BS and consequently to estimate the label arrival times and tissue perfusion in seven participants. A second experiment estimated the BS cerebral vascular reactivity (CVR) to hypercapnia in 10 participants. Images were acquired with a gradient-echo sequence with two spiral interleaves and short echo time (TE=2.7 ms). Data were analyzed with a two-compartment model, including a tissue and arterial component. In both experiments, perfusion in the BS was significantly lower than in cortical gray matter (repeated measures analysis of variance (RM-ANOVA), P<0.05), which is as expected since the BS consists of gray and white matter, the latter typically showing lower perfusion. The BS CVR found here is comparable to previous reports obtained with positron emission tomography (PET) imaging. Multi-inversion time pulsed ASL in combination with a two-compartment signal model can be used to assess BS perfusion and CVR.
dc.identifier.citationWarnert, E. A., Harris, A. D., Murphy, K., Saxena, N., Tailor, N., Jenkins, N. S., Hall, J. E., & Wise, R. G. (2014). In vivo Assessment of Human Brainstem Cerebrovascular Function: A Multi-Inversion Time Pulsed Arterial Spin Labelling Study. Journal of Cerebral Blood Flow & Metabolism, 34(6), 956–963. https://doi.org/10.1038/jcbfm.2014.39
dc.identifier.doi10.1038/jcbfm.2014.39
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/38527
dc.identifier.issn0271-678X
dc.identifier.urihttp://hdl.handle.net/1880/112935
dc.language.isoeng
dc.publisherSAGE Publications
dc.publisher.hasversionPublisher's version
dc.publisher.policyhttps://uk.sagepub.com/en-gb/eur/journal-author-archiving-policies-and-re-use
dc.rights© 2014 ISCBFM All rights reserved
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/
dc.subjectarterial spin labelling
dc.subjectbrainstem
dc.subjectcerebral hemodynamics
dc.titleIn vivo Assessment of Human Brainstem Cerebrovascular Function: A Multi-Inversion Time Pulsed Arterial Spin Labelling Study
dc.typejournal article
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