Effects of a Short Course of Inhaled Corticosteroids in Noneosinophilic Asthmatic Subjects

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dc.contributor.authorLemière, Catherine
dc.contributor.authorTremblay, Caroline
dc.contributor.authorFitzGerald, Mark
dc.contributor.authorAaron, Shawn D
dc.contributor.authorLeigh, Richard
dc.contributor.authorBoulet, Louis-Philippe
dc.contributor.authorMartin, James G
dc.contributor.authorNair, Parameswaran
dc.contributor.authorOlivenstein, Ronald
dc.contributor.authorChaboillez, Simone
dc.date.accessioned2018-09-27T11:56:51Z
dc.date.available2018-09-27T11:56:51Z
dc.date.issued2011-01-01
dc.date.updated2018-09-27T11:56:51Z
dc.description.abstractBACKGROUND: Noneosinophilic asthma has been regarded as a distinct phenotype characterized by a poor response to inhaled corticosteroids (ICS).OBJECTIVE: To determine whether noneosinophilic, steroid-naive asthmatic subjects show an improvement in asthma control, asthma symptoms and spirometry after four weeks of treatment with ICS, and whether they further benefit from the addition of a long-acting beta-2 agonists to ICS.METHODS: A randomized, double-blind, placebo-controlled, multicentre study comparing the efficacy of placebo versus inhaled fluticasone propionate 250 μg twice daily for four weeks in mildly uncontrolled, steroid-naive asthmatic subjects with a sputum eosinophil count ≤2%. This was followed by an open-label, four-week treatment period with fluticasone propionate 250 μg/salmeterol 50 μg, twice daily for all subjects.RESULTS: After four weeks of double-blind treatment, there was a statistically significant and clinically relevant improvement in the mean (± SD) Asthma Control Questionnaire score in the ICS-treated group (n=6) (decrease of 1.0±0.5) compared with the placebo group (n=6) (decrease of 0.09±0.4) (P=0.008). Forced expiratory volume in 1 s declined in the placebo group (−0.2±0.2 L) and did not change in the ICS group (0.04±0.1 L) after four weeks of treatment (P=0.02). The open-label treatment with fluticasone propionate 250 μg/salmeterol 50 μg did not produce additional improvements in those who were previously treated for four weeks with inhaled fluticasone alone.CONCLUSION: A clinically important and statistically significant response to ICS was observed in mildly uncontrolled noneosinophilic asthmatic subjects.
dc.description.versionPeer Reviewed
dc.identifier.citationCatherine Lemière, Caroline Tremblay, Mark FitzGerald, et al., “Effects of a Short Course of Inhaled Corticosteroids in Noneosinophilic Asthmatic Subjects,” Canadian Respiratory Journal, vol. 18, no. 5, pp. 278-282, 2011. doi:10.1155/2011/108079
dc.identifier.doihttps://doi.org/10.1155/2011/108079
dc.identifier.urihttp://hdl.handle.net/1880/108400
dc.language.rfc3066en
dc.rights.holderCopyright © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleEffects of a Short Course of Inhaled Corticosteroids in Noneosinophilic Asthmatic Subjects
dc.typeJournal Article
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