Novel Clinical and Diagnostic Aspects of Antineutrophil Cytoplasmic Antibodies

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dc.contributor.authorSchulte-Pelkum, Johannes
dc.contributor.authorRadice, Antonella
dc.contributor.authorNorman, Gary L.
dc.contributor.authorLόpez Hoyos, Marcos
dc.contributor.authorLakos, Gabriella
dc.contributor.authorBuchner, Carol
dc.contributor.authorMusset, Lucile
dc.contributor.authorMiyara, Makoto
dc.contributor.authorStinton, Laura
dc.contributor.authorMahler, Michael
dc.date.accessioned2018-09-27T11:34:14Z
dc.date.available2018-09-27T11:34:14Z
dc.date.issued2014-06-05
dc.date.updated2018-09-27T11:34:14Z
dc.description.abstractAntineutrophil cytoplasmic antibodies (ANCA) are the serological hallmark of some idiopathic systemic vasculitides. Besides the investigation of ANCA-associated vasculitis (AAV) and constant effort for a standardized nomenclature and classification of the AAV, a main focus of research during the last few years has been to constantly improve the performance of enzyme immunoassays. With the latest so called third generation ELISA, this goal seemed to be fulfilled. The International Consensus Statement on Testing and Reporting of ANCA gave recommendations for standardized strategies for the serological diagnosis of ANCA. New developments now target the system immanent drawbacks of the respective diagnostic methods, be it the need for batching and the long time to result for ELISA, or the high likelihood of error and subjectivity of indirect immunofluorescence (IIF). Random access technology and multiplexing for solid phase assays as well as digital imaging for IIF are tools which may help to expedite and simplify routine diagnostics in the lab and in emergency settings. Recent findings indicate that PR3-ANCA have clinical utility beyond the diagnosis of AAV. PR3-ANCA can also serve as an aid for the differentiation between ulcerative colitis (UC) and Crohn’s disease (CrD) and the stratification of UC patients. This review provides a detailed review of what is known about ANCA and highlights the latest research and state-of-the-art developments in this area.
dc.description.versionPeer Reviewed
dc.identifier.citationJohannes Schulte-Pelkum, Antonella Radice, Gary L. Norman, et al., “Novel Clinical and Diagnostic Aspects of Antineutrophil Cytoplasmic Antibodies,” Journal of Immunology Research, vol. 2014, Article ID 185416, 12 pages, 2014. doi:10.1155/2014/185416
dc.identifier.doihttps://doi.org/10.1155/2014/185416
dc.identifier.urihttp://hdl.handle.net/1880/108204
dc.language.rfc3066en
dc.rights.holderCopyright © 2014 Johannes Schulte-Pelkum et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleNovel Clinical and Diagnostic Aspects of Antineutrophil Cytoplasmic Antibodies
dc.typeJournal Article
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