Impact of Homeostasis Disruption on the Structure and Function of Murine Articular Cartilage
Date
2023-09-12
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Abstract
Articular cartilage plays a vital role in facilitating pain-free movement and load distribution in synovial joints, such as the knee. Owing to its complex structure-functional requirements and limited regenerative capacity, articular cartilage is particularly vulnerable to deterioration triggered by intrinsic and extrinsic insults. For instance, abnormal loading, trauma and aging can disrupt cellular, anatomical, and functional homeostasis within the knee joint and/or articular cartilage microenvironment, contributing to the pathogenesis of tissue degradation and degenerative joint diseases, particularly osteoarthritis (OA). In this context, it is essential to understand how cartilage and the joint microenvironment respond to differential levels of tissue homeostatic disruption and the resulting implication on remodeling and repair outcomes. In this multifaceted study, I employed several transgenic mouse models in conjunction with histological, imaging, and mechanical testing modalities to deepen our understanding of structural and functional changes associated with degeneration and regeneration of murine articular cartilage.
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Keywords
Osteoarthritis, Articular cartilage, Stem Cells
Citation
Oliveira Masson, A. (2023). Impact of homeostasis disruption on the structure and function of murine articular cartilage (Doctoral thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.