Impact of Homeostasis Disruption on the Structure and Function of Murine Articular Cartilage

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dc.contributor.advisorKrawetz, Roman
dc.contributor.authorOliveira Masson, Anand
dc.contributor.committeememberEdwards, William Brent
dc.contributor.committeememberBiernaskie, Jeffrey Allan
dc.date2023-11
dc.date.accessioned2023-09-15T18:32:26Z
dc.date.available2023-09-15T18:32:26Z
dc.date.issued2023-09-12
dc.description.abstractArticular cartilage plays a vital role in facilitating pain-free movement and load distribution in synovial joints, such as the knee. Owing to its complex structure-functional requirements and limited regenerative capacity, articular cartilage is particularly vulnerable to deterioration triggered by intrinsic and extrinsic insults. For instance, abnormal loading, trauma and aging can disrupt cellular, anatomical, and functional homeostasis within the knee joint and/or articular cartilage microenvironment, contributing to the pathogenesis of tissue degradation and degenerative joint diseases, particularly osteoarthritis (OA). In this context, it is essential to understand how cartilage and the joint microenvironment respond to differential levels of tissue homeostatic disruption and the resulting implication on remodeling and repair outcomes. In this multifaceted study, I employed several transgenic mouse models in conjunction with histological, imaging, and mechanical testing modalities to deepen our understanding of structural and functional changes associated with degeneration and regeneration of murine articular cartilage.
dc.identifier.citationOliveira Masson, A. (2023). Impact of homeostasis disruption on the structure and function of murine articular cartilage (Doctoral thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.
dc.identifier.urihttps://hdl.handle.net/1880/117035
dc.language.isoen
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgary
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectOsteoarthritis
dc.subjectArticular cartilage
dc.subjectStem Cells
dc.subject.classificationEngineering--Biomedical
dc.subject.classificationEducation--Health
dc.titleImpact of Homeostasis Disruption on the Structure and Function of Murine Articular Cartilage
dc.typedoctoral thesis
thesis.degree.disciplineEngineering – Biomedical
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameDoctor of Philosophy (PhD)
ucalgary.thesis.accesssetbystudentI do not require a thesis withhold – my thesis will have open access and can be viewed and downloaded publicly as soon as possible.
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