Structure, function, and evolution of linear replicons in Borrelia

Simple item page
dc.contributor.authorChaconas, George
dc.contributor.authorKobryn, Kerri
dc.date.accessioned2021-04-23T19:20:43Z
dc.date.available2021-04-23T19:20:43Z
dc.date.issued2010-06-10
dc.description.abstractSpirochetes of the genus Borrelia include important human pathogens that cause Lyme borreliosis and relapsing fever. The genomes of Borrelia species can be composed of up to 24 DNA molecules, most of which are linear. The plasmid content and linear replicon sequence arrangement vary widely between isolates. The linear replicons are terminated by covalently closed DNA hairpins or hairpin telomeres. Replication of these elements involves a unique reaction, called telomere resolution, to produce hairpin telomeres from replicative intermediates. The telomere resolvase, ResT, is thought to contribute to the genetic flux of the linear molecules by promoting stabilized telomere fusions. Telomere resolvases are related to the tyrosine recombinases and ResT can generate the crucial reaction intermediate of this class of enzyme, the Holliday junction. This observation has led to the proposal that telomere resolvases evolved from tyrosine recombinases inducing DNA linearization in the genomes that acquired them.en_US
dc.description.grantingagencyCanadian Institutes of Health Research (CIHR)en_US
dc.identifier.citationChaconas, G., & Kobryn, K. (2010). Structure, function, and evolution of linear replicons in Borrelia. Annual review of microbiology, 64, 185-202.en_US
dc.identifier.doihttp://dx.doi.org/10.1146/annurev.micro.112408.134037en_US
dc.identifier.grantnumberMOP-53086en_US
dc.identifier.urihttp://hdl.handle.net/1880/113311
dc.language.isoengen_US
dc.publisherAnnual Reviewsen_US
dc.publisher.departmentBiochemistry & Molecular Biologyen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.hasversionacceptedVersionen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.publisher.institutionUniversity of Saskatchewanen_US
dc.publisher.policyhttps://www.annualreviews.org/page/about/copyright-and-permissionsen_US
dc.subjecttelomere resolutionen_US
dc.subjectprotelomeraseen_US
dc.subjecttelomere resolvaseen_US
dc.subjectlinear DNAen_US
dc.subjecthairpin telomereen_US
dc.titleStructure, function, and evolution of linear replicons in Borreliaen_US
dc.typejournal articleen_US
ucalgary.item.requestcopyfalseen_US
ucalgary.scholar.levelFacultyen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Chaconas and Kobryn Jan 04.pdf
Size:
1.43 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.92 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Cumming School of Medicine Research & Publications