Depressive-like behaviour of mice lacking cellular prion protein

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dc.contributor.authorBonfield, Stephan P.
dc.contributor.authorZamponi, Gerald W.
dc.contributor.authorGadotti, Vinícius Maria
dc.date.accessioned2018-05-22T20:25:57Z
dc.date.available2018-05-22T20:25:57Z
dc.date.issued2012-02
dc.description.abstractCellular Prion Protein (PrP(C)) is known to mediate a protective role in several neurological conditions such as ischemia and epilepsy. However, so far, little information is available concerning the role of PrP(C) in psychiatric disorders such as depression. Here, we have used PrP(C) null mice to examine a putative role of PrP(C) in depressive-like states. Prion protein null mice exhibited depressive-like behaviour when compared to wild-type mice in both the Forced Swimming Test (FST) and Tail Suspension Test (TST). The clinical antidepressant drug imipramine and the NMDA receptor antagonist MK-801 reversed the depressive-like behaviour observed for knockout mice in the TST. The present data thus indicate that PrP(C) exerts a critical role in modulating the depressive-like state in mice, reinforcing the notion that PrP(C) might be associated with alterations in mood disorder states, and suggests a possible role of PrP(C) as a potential drug target for treating depressive disorders.en_US
dc.identifier.citationGadotti, V. M., Bonfield, S. P., & Zamponi, G. W. (2012). Depressive-like behaviour of mice lacking cellular prion protein. Behavioural Brain Research, 227(2), 319–323. https://doi.org/10.1016/j.bbr.2011.03.012en_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.bbr.2011.03.012en_US
dc.identifier.urihttp://hdl.handle.net/1880/106650
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.publisher.departmentPhysiology & Pharmacologyen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.titleDepressive-like behaviour of mice lacking cellular prion proteinen_US
dc.typeunknown
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