Anticoagulant Related Nephropathy Induced by Dabigatran

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dc.contributor.authorSharfuddin, Nazia
dc.contributor.authorNourbakhsh, Mahra
dc.contributor.authorBox, Alan
dc.contributor.authorBenediktsson, Hallgrimur
dc.contributor.authorMuruve, Daniel A.
dc.date.accessioned2018-12-16T07:07:45Z
dc.date.available2018-12-16T07:07:45Z
dc.date.issued2018-12-09
dc.date.updated2018-12-16T07:07:44Z
dc.description.abstractWe describe a case of biopsy-proven dabigatran related nephropathy in a patient without underlying IgA nephropathy. To date, dabigatran related nephropathy was only reported in patients with concurrent or undiagnosed IgA nephropathy, suggesting that it may predispose patients to dabigatran associated injury. The patient is an 81-year-old woman with multiple medical comorbidities, including nonvalvular atrial fibrillation, who was anticoagulated with dabigatran. She presented to hospital with acute kidney injury in the setting of volume overload. Her estimated glomerular filtration rate decreased from a baseline of 57 mL/min/1.73 m2 to 4 mL/min/1.73 m2, necessitating hemodialysis. Renal ultrasound findings, fractional excretion of sodium, and urinalysis suggested acute kidney injury. Renal biopsy showed acute tubular injury, tubular red blood cell casts, and an absence of active glomerulonephritis, similar to the pathological findings of warfarin related nephropathy. A diagnosis of anticoagulant related nephropathy secondary to dabigatran was therefore established. This case demonstrates that dabigatran, like warfarin, may increase tubular bleeding risk in patients, irrespective of underlying kidney or glomerular disease.
dc.description.versionPeer Reviewed
dc.identifier.citationNazia Sharfuddin, Mahra Nourbakhsh, Alan Box, Hallgrimur Benediktsson, and Daniel A. Muruve, “Anticoagulant Related Nephropathy Induced by Dabigatran,” Case Reports in Nephrology, vol. 2018, Article ID 7381505, 7 pages, 2018. doi:10.1155/2018/7381505
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/34975
dc.identifier.urihttp://dx.doi.org/10.1155/2018/7381505
dc.identifier.urihttp://hdl.handle.net/1880/109355
dc.language.rfc3066en
dc.rights.holderCopyright © 2018 Nazia Sharfuddin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleAnticoagulant Related Nephropathy Induced by Dabigatran
dc.typeJournal Article
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