Reduced Functional Connectivity in Adults with Persistent Post-Concussion Symptoms: A Functional Near-Infrared Spectroscopy Study

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dc.contributor.authorHocke, Lia Maria
dc.contributor.authorDuszynski, Chris C.
dc.contributor.authorDebert, Chantel T.
dc.contributor.authorDleikan, Diane
dc.contributor.authorDunn, Jeff F.
dc.date.accessioned2018-10-26T15:05:34Z
dc.date.available2018-10-26T15:05:34Z
dc.date.issued2018-06-01
dc.description.abstractConcussion, or mild traumatic brain injury (mTBI), accounts for ∼80% of all TBIs across North America. The majority of mTBI patients recover within days to weeks; however, 14-36% of the time, acute mTBI symptoms persist for months or even years and develop into persistent post-concussion symptoms (PPCS). There is a need to find biomarkers in patients with PPCS, to improve prognostic ability and to provide insight into the pathophysiology underlying chronic symptoms. Recent research has pointed toward impaired network integrity and cortical communication as a biomarker. In this study we investigated functional near-infrared spectroscopy (fNIRS) as a technique to assess cortical communication deficits in adults with PPCS. Specifically, we aimed to identify cortical communication patterns in prefrontal and motor areas during rest and task, in adult patients with persistent symptoms. We found that (1) the PPCS group showed reduced connectivity compared with healthy controls, (2) increased symptom severity correlated with reduced coherence, and (3) connectivity differences were best distinguishable during task and in particular during the working memory task (n-back task) in the right and left dorsolateral prefrontal cortex (DLPFC). These data show that reduced brain communication may be associated with the pathophysiology of mTBI and that fNIRS, with a relatively simple acquisition paradigm, may provide a useful biomarker of this injury.en_US
dc.description.grantingagencyCanadian Institutes of Health Research - Other Programsen_US
dc.description.grantingagencyNatural Sciences and Engineering Research Council - Collaborative Research & Development Granten_US
dc.identifier.citationHocke, L. M., Duszynski, C. C., Debert, C. T., Dleikan, D., & Dunn, J. F. (2018). Reduced functional connectivity in adults with persistent post-concussion symptoms - a functional near-infrared spectroscopy study. "Journal of Neurotrauma", 35, 1-9. https:// doi.org/10.1089/neu.2017.5365.en_US
dc.identifier.doi10.1089/neu.2017.5365en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33896
dc.identifier.issn0897-7151
dc.identifier.urihttp://hdl.handle.net/1880/108923
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Inc.en_US
dc.publisher.departmentClinical Neurosciencesen_US
dc.publisher.departmentRadiologyen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.policyhttp://www.sherpa.ac.uk/romeo/issn/0897-7151/en_US
dc.rightsThis Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly crediteden_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.subjectDLPFCen_US
dc.subjectconcussionen_US
dc.subjectfNIRSen_US
dc.subjectfunctional connectivityen_US
dc.subjectmTBIen_US
dc.subjectworking memory tasken_US
dc.titleReduced Functional Connectivity in Adults with Persistent Post-Concussion Symptoms: A Functional Near-Infrared Spectroscopy Studyen_US
dc.typejournal articleen_US
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