An Assessment of the Impact of Familial Resemblance and Other Factors on Bone Health Parameters in Daughter-Mother Pairs
Date
2024-06-28
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Abstract
Older females face a higher prevalence of osteoporosis and incidence of fragility fracture than older males. Evidence suggests that the groundwork that contributes to these conditions is laid in adolescence or young adulthood. In addition to the effects of lifestyle on bone health, there is also a high degree of heritability. Previous research has investigated and accounted for this by using mother-daughter study designs. This thesis aimed to determine the impact of heritability versus various factors (i.e., lifestyle, health, and reproductive history) on bone density, area and microarchitecture. Mother-daughter studies were compiled in a scoping review to determine trends in methodologies and findings. The results from the review showed that, regardless of age or reproductive developmental stage, bone density largely demonstrates familial resemblance and heritability. This scoping review informed the analysis of a pre-existing cohort of 39 paired youngadult daughters and menopause-aged mothers. The cohort data included health and reproductive history, current calcium intake, physical activity level, body composition, areal bone mineral density (aBMD) at the lumbar spine (LS), femoral neck (FN), total hip (TH), whole body (WB) from dual X-ray absorptiometry (DXA), and bone microarchitecture, cross-sectional area (CSA) and volumetric BMD (vBMD) at the radius and tibia from high-resolution quantitative computed tomography (HR-pQCT). No heritability was seen for DXA-derived aBMD or HR-pQCT-derived total vBMD, but there was for radial and tibial CSA and microarchitecture, and tibial vBMD. Tibial parameters were more heritable than radial, and CSA was more heritable than density or microarchitecture. The percentage of variance accounted for by lifestyle and heritability for aBMD was 10% to 45%, for radial parameters was 11% to 70% and for tibial parameters was 29% to 66%. Therefore, there is familial resemblance in bone health parameters between menopause-aged mothers and young-adult daughters.
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Bone, DXA, Dual X-ray Absorptiometry, HR-pQCT, High Resolution Peripheral Computed Tomography, Mother, Daughter, Heritability, Familial Resemblance, Bone Density, Bone Microarchitecture, Female Health, Women's Health
Citation
Boisvert, N. M. J. (2024). An assessment of the impact of familial resemblance and other factors on bone health parameters in daughter-mother pairs (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.