An Assessment of the Impact of Familial Resemblance and Other Factors on Bone Health Parameters in Daughter-Mother Pairs

Boisvert, Nicole Marie Jeanne

An Assessment of the Impact of Familial Resemblance and Other Factors on Bone Health Parameters in Daughter-Mother Pairs

dc.contributor.advisor	Doyle-Baker, Patricia K.
dc.contributor.author	Boisvert, Nicole Marie Jeanne
dc.contributor.committeemember	Burt, Lauren A.
dc.contributor.committeemember	Tough, Suzanne C.
dc.date	2024-11
dc.date.accessioned	2024-07-04T20:04:59Z
dc.date.available	2024-07-04T20:04:59Z
dc.date.issued	2024-06-28
dc.description.abstract	Older females face a higher prevalence of osteoporosis and incidence of fragility fracture than older males. Evidence suggests that the groundwork that contributes to these conditions is laid in adolescence or young adulthood. In addition to the effects of lifestyle on bone health, there is also a high degree of heritability. Previous research has investigated and accounted for this by using mother-daughter study designs. This thesis aimed to determine the impact of heritability versus various factors (i.e., lifestyle, health, and reproductive history) on bone density, area and microarchitecture. Mother-daughter studies were compiled in a scoping review to determine trends in methodologies and findings. The results from the review showed that, regardless of age or reproductive developmental stage, bone density largely demonstrates familial resemblance and heritability. This scoping review informed the analysis of a pre-existing cohort of 39 paired youngadult daughters and menopause-aged mothers. The cohort data included health and reproductive history, current calcium intake, physical activity level, body composition, areal bone mineral density (aBMD) at the lumbar spine (LS), femoral neck (FN), total hip (TH), whole body (WB) from dual X-ray absorptiometry (DXA), and bone microarchitecture, cross-sectional area (CSA) and volumetric BMD (vBMD) at the radius and tibia from high-resolution quantitative computed tomography (HR-pQCT). No heritability was seen for DXA-derived aBMD or HR-pQCT-derived total vBMD, but there was for radial and tibial CSA and microarchitecture, and tibial vBMD. Tibial parameters were more heritable than radial, and CSA was more heritable than density or microarchitecture. The percentage of variance accounted for by lifestyle and heritability for aBMD was 10% to 45%, for radial parameters was 11% to 70% and for tibial parameters was 29% to 66%. Therefore, there is familial resemblance in bone health parameters between menopause-aged mothers and young-adult daughters.
dc.identifier.citation	Boisvert, N. M. J. (2024). An assessment of the impact of familial resemblance and other factors on bone health parameters in daughter-mother pairs (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.
dc.identifier.uri	https://hdl.handle.net/1880/119069
dc.identifier.uri	https://doi.org/10.11575/PRISM/46665
dc.language.iso	en
dc.publisher.faculty	Kinesiology
dc.publisher.institution	University of Calgary
dc.rights	University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subject	Bone
dc.subject	DXA
dc.subject	Dual X-ray Absorptiometry
dc.subject	HR-pQCT
dc.subject	High Resolution Peripheral Computed Tomography
dc.subject	Mother
dc.subject	Daughter
dc.subject	Heritability
dc.subject	Familial Resemblance
dc.subject	Bone Density
dc.subject	Bone Microarchitecture
dc.subject	Female Health
dc.subject	Women's Health
dc.subject.classification	Radiology
dc.subject.classification	Human Development
dc.subject.classification	Health Sciences
dc.subject.classification	Health Sciences
dc.title	An Assessment of the Impact of Familial Resemblance and Other Factors on Bone Health Parameters in Daughter-Mother Pairs
dc.type	master thesis
thesis.degree.discipline	Kinesiology
thesis.degree.grantor	University of Calgary
thesis.degree.name	Master of Science (MSc)
ucalgary.thesis.accesssetbystudent	I do not require a thesis withhold – my thesis will have open access and can be viewed and downloaded publicly as soon as possible.