Modular Development of Gray Matter in Childhood and Adolescence

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The brain is becoming increasingly understood by its networks rather than regional architecture. Understanding the development of networks in the healthy human brain during childhood and adolescence is an important foundational step in determining what may go wrong in neurodevelopmental disorders. Moreover, it has been hypothesized that networks of functionally coupled regions may develop in parallel. In this thesis regions of the cerebral cortex undergoing synchronized development in anatomical structure were found and described. The findings indicated that cortical thickness, surface area, and volume underwent different developmental trajectories and showed differential synchronized developmental patterns. Cortical thickness based modules were distributed while surface area and volume based modules showed anterior to posterior organization. Additionally, comparisons between developmental modules and well-established functional networks in the brain found only partial overlap. This suggests that neuronal networks do not singularly arise from similar development of cortical regions.
Neuroscience, Human Development
Krongold, M. (2015). Modular Development of Gray Matter in Childhood and Adolescence (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from doi:10.11575/PRISM/26974