Endocarditis caused by an oral taxon species of Bergeyella identified by partial 16S rDNA sequencing: case report and review of the literature

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dc.contributor.authorClark, Lauren
dc.contributor.authorParkins, Michael D
dc.contributor.authorChow, Barbara L
dc.contributor.authorLynch, Tarah
dc.contributor.authorChurch, Deirdre
dc.date.accessioned2017-09-06T16:31:34Z
dc.date.available2017-09-06T16:31:34Z
dc.date.issued2017
dc.description.abstractBergeyella spp bacteremia is a rare cause of infective endocarditis and is typically associated with animal contact. This case report presents a case of culture-negative endocarditis caused by Bergeyella spp oral taxon 422 in a 49-year-old man with severe periodontal disease but no animal contact. Multiple sets of blood cultures were negative, but broad-range 16S rDNA polymerase chain reaction (PCR) amplification and sequencing repeatedly detected this organism in the patient’s bloodstream. Empiric broad-spectrum antibiotic treatment against Bergeyella spp resulted in resolution of clinical symptoms, resolution of bloodstream infection, and cure. This is the first human case of endocarditis caused by an oral-associated species of Bergeyella described in the literature. Culture-negative endocarditis due to Bergeyella spp from severe periodontal disease may be missed unless molecular detection methods are used.en_US
dc.description.refereedYesen_US
dc.description.sponsorshipOpen Access Authors Funden_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33833
dc.identifier.urihttp://hdl.handle.net/1880/52207
dc.language.isoenen_US
dc.publisherUniversity of Toronto Pressen_US
dc.publisher.departmentMedicineen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.publisher.urlhttp://jammi.utpjournals.press/en_US
dc.rightsAttribution Non-Commercial 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectendocarditisen_US
dc.subjectBergeyella sppen_US
dc.subjectperiodontal diseaseen_US
dc.subjectbroad-range 16S PCRen_US
dc.titleEndocarditis caused by an oral taxon species of Bergeyella identified by partial 16S rDNA sequencing: case report and review of the literatureen_US
dc.typejournal article
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