Urinary Tract Infections and Preeclampsia among Pregnant Women Attending Two Hospitals in Mwanza City, Tanzania: A 1:2 Matched Case-Control Study

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dc.contributor.authorKaduma, Joshua
dc.contributor.authorSeni, Jeremiah
dc.contributor.authorChuma, Clotilda
dc.contributor.authorKirita, Richard
dc.contributor.authorMujuni, Fridolin
dc.contributor.authorMushi, Martha F.
dc.contributor.authorvan der Meer, Frank
dc.contributor.authorMshana, Stephen E.
dc.date.accessioned2019-05-08T11:05:44Z
dc.date.available2019-05-08T11:05:44Z
dc.date.issued2019-03-27
dc.date.updated2019-05-08T11:05:43Z
dc.description.abstractUrinary tract infection (UTI) and preeclampsia are common among pregnant women and are associated with adverse maternal-fetal and neonatal outcomes. Despite this, limited information exists on the association between UTIs and preeclampsia in Tanzania to guide specific management and thereby averting the adverse outcomes. A 1:2 matched case-control study (by age and gravidity) involving 131 pregnant women with preeclampsia (cases) and 262 without preeclampsia (controls) was conducted. Sociodemographic and clinical information was collected using a questionnaire. Midstream urine samples were collected during admission for culture and antimicrobial susceptibility testing (AST). Out of 393 pregnant women enrolled, 110 (28.0%), 95% CI: 23.8%-32.7%, had significant bacteriuria [cases: 50.4% (66/131) and control: 16.8% (44/262)]. Pregnant women with preeclampsia had 7.7 odds of having significant bacteriuria than those without preeclampsia [OR=7.7, 95% CI (4.11-14.49); p-value ud_less_than0.001]. Escherichia coli, 50 (45.5%), and Klebsiella spp., 25 (23.6%), predominated, and resistance to gentamicin, ceftriaxone, and piperacillin-tazobactam ranged from 9.0% to 29.0% in these dominant species. Extended spectrum beta lactamases (ESBL) production in Escherichia coli and Klebsiella spp. was 18.0% (9/50) and 15.4% (4/26), respectively. Routine urine culture and AST among pregnant women with preeclampsia should be introduced in the antenatal clinics to ensure prompt management. Delineation of maternal-fetal and neonatal outcomes among pregnant women with preeclampsia and UTIs would be of interest in future studies.
dc.description.versionPeer Reviewed
dc.identifier.citationJoshua Kaduma, Jeremiah Seni, Clotilda Chuma, et al., “Urinary Tract Infections and Preeclampsia among Pregnant Women Attending Two Hospitals in Mwanza City, Tanzania: A 1:2 Matched Case-Control Study,” BioMed Research International, vol. 2019, Article ID 3937812, 8 pages, 2019. doi:10.1155/2019/3937812
dc.identifier.urihttp://dx.doi.org/10.1155/2019/3937812
dc.identifier.urihttp://hdl.handle.net/1880/110312
dc.identifier.urihttps://dx.doi.org/10.11575/PRISM/36488
dc.language.rfc3066en
dc.rights.holderCopyright © 2019 Joshua Kaduma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleUrinary Tract Infections and Preeclampsia among Pregnant Women Attending Two Hospitals in Mwanza City, Tanzania: A 1:2 Matched Case-Control Study
dc.typeJournal Article
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