Control of low-threshold exocytosis by T-type calcium channels

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dc.contributor.authorWeiss, Norbert
dc.contributor.authorZamponi, Gerald W.
dc.date.accessioned2018-05-29T18:54:58Z
dc.date.available2018-05-29T18:54:58Z
dc.date.issued2013-07
dc.description.abstractLow-voltage-activated (LVA) T-type Ca²⁺ channels differ from their high-voltage-activated (HVA) homologues by unique biophysical properties. Hence, whereas HVA channels convert action potentials into intracellular Ca²⁺ elevations, T-type channels control Ca²⁺ entry during small depolarizations around the resting membrane potential. They play an important role in electrical activities by generating low-threshold burst discharges that occur during various physiological and pathological forms of neuronal rhythmogenesis. In addition, they mediate a previously unrecognized function in the control of synaptic transmission where they directly trigger the release of neurotransmitters at rest. In this review, we summarize our present knowledge of the role of T-type Ca²⁺ channels in vesicular exocytosis, and emphasize the critical importance of localizing the exocytosis machinery close to the Ca²⁺ source for reliable synaptic transmission. This article is part of a Special Issue entitled: Calcium channels.en_US
dc.identifier.citationWeiss, N., & Zamponi, G. W. (2013, July). Control of low-threshold exocytosis by T-type calcium channels. Biochimica et Biophysica Acta - Biomembranes. https://doi.org/10.1016/j.bbamem.2012.07.031en_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.bbamem.2012.07.031en_US
dc.identifier.urihttp://hdl.handle.net/1880/106704
dc.identifier.urihttps://doi.org/10.11575/PRISM/43837
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.publisher.departmentPhysiology & Pharmacologyen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.titleControl of low-threshold exocytosis by T-type calcium channelsen_US
dc.typejournal articleen_US
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