Latent trait cortisol (LTC) during pregnancy: Composition, continuity, change, and concomitants

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dc.contributor.authorGiesbrecht, Gerald
dc.contributor.authorBryce, Crystal
dc.contributor.authorLetourneau, Nicole
dc.contributor.authorGranger, Douglas
dc.contributor.authorAPrON Study Team
dc.date.accessioned2016-01-04T20:31:20Z
dc.date.available2016-01-04T20:31:20Z
dc.date.issued2015-08
dc.descriptionAuthor's accepted manuscript deposited according to Elsevier sharing policies http://www.elsevier.com/about/company-information/policies/policy-faq November 18th, 2015en_US
dc.description.abstractIndividual differences in the activity of the hypothalamic pituitary adrenal (HPA) axis are often operationalized using summary measures of cortisol that are taken to represent stable individual differences. Here we extend our understanding of a novel latent variable approach to latent trait cortisol (LTC) as a measure of trait-like HPA axis function during pregnancy. Pregnant women (n=380) prospectively collected 8 diurnal saliva samples (4 samples/day, 2 days) within each trimester. Saliva was assayed for cortisol. Confirmatory factor analyses were used to fit LTC models to early morning and daytime cortisol. For individual trimester data, only the daytime LTC models had adequate fit. These daytime LTC models were strongly correlated between trimesters and stable over pregnancy. Daytime LTC was unrelated to the cortisol awakening response and the daytime slope but strongly correlated with the area under the curve from ground. The findings support the validity of LTC as a measure of cortisol during pregnancy and suggest that it is not affected by pregnancy-related changes in HPA axis function.en_US
dc.description.refereedYesen_US
dc.identifier.citationGiesbrecht, G.F., Bryce, C., Letourneau, N., & Granger, D. (2015). Latent trait cortisol (LTC) during pregnancy: Composition, continuity, change, and concomitants. Psychoneuroendocrinology, 62 (August), 149-158.en_US
dc.identifier.doi10.1016/j.psyneuen.2015.08.009
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33638
dc.identifier.urihttp://hdl.handle.net/1880/51039
dc.language.isoenen_US
dc.publisherPsychoneuroendocrinologyen_US
dc.publisher.corporateUniversity of Calgary
dc.publisher.departmentDepartment of Paediatricsen_US
dc.publisher.facultyMedicineen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.publisher.urlhttp://www.journals.elsevier.com/psychoneuroendocrinology/en_US
dc.rightsAttribution Non-Commercial No Derivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectLatent trait cortisolen_US
dc.subjectPregnancyen_US
dc.subjectStabilityen_US
dc.subjectCortisol awakening responseen_US
dc.subjectArea under the curveen_US
dc.subjectDaytime slopeen_US
dc.titleLatent trait cortisol (LTC) during pregnancy: Composition, continuity, change, and concomitantsen_US
dc.typejournal article
thesis.degree.disciplinePaediatrics
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