The role of the gacs gene in the development of pseudomonas aeruginosa and pseudomonas chlororaphis small colony variants as a response to environmental stress
Date
2007
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Biofilms are the most prevalent form of microbial growth exhibiting phenotypic and physiological changes not observed in planktonic populations. The GacA/S two component regulatory system in Pseudomonas spp. is implicated in the formation of biofilms and the phenotypic changes that occur within them. When the gacS gene encoding the sensor kinase component is non-functional, bacteria demonstrate a decreased capacity for biofilm formation and antimicrobial tolerance. Furthermore, exposure of the mutant strain to stress results in the formation of stable small colony variants (SCV). The study of SCVs yielded data suggesting that their formation may be dependent on the type of stress, which induces their formation. This study involved the generation of numerous SCV s from multiple challenges and their subsequent exposure to antimicrobial agents. The results indicate that SCV s formed under different conditions of stress behave differently from others when exposed to a variety of antimicrobial agents.
Description
Bibliography: p. 113-120
Some pages are in colour.
Some pages are in colour.
Keywords
Citation
Foglia, G. (2007). The role of the gacs gene in the development of pseudomonas aeruginosa and pseudomonas chlororaphis small colony variants as a response to environmental stress (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/1386