The role of the gacs gene in the development of pseudomonas aeruginosa and pseudomonas chlororaphis small colony variants as a response to environmental stress

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dc.contributor.advisorCeri, Howard
dc.contributor.authorFoglia, Ginevra
dc.date.accessioned2017-12-18T21:27:05Z
dc.date.available2017-12-18T21:27:05Z
dc.date.issued2007
dc.descriptionBibliography: p. 113-120en
dc.descriptionSome pages are in colour.en
dc.description.abstractBiofilms are the most prevalent form of microbial growth exhibiting phenotypic and physiological changes not observed in planktonic populations. The GacA/S two component regulatory system in Pseudomonas spp. is implicated in the formation of biofilms and the phenotypic changes that occur within them. When the gacS gene encoding the sensor kinase component is non-functional, bacteria demonstrate a decreased capacity for biofilm formation and antimicrobial tolerance. Furthermore, exposure of the mutant strain to stress results in the formation of stable small colony variants (SCV). The study of SCVs yielded data suggesting that their formation may be dependent on the type of stress, which induces their formation. This study involved the generation of numerous SCV s from multiple challenges and their subsequent exposure to antimicrobial agents. The results indicate that SCV s formed under different conditions of stress behave differently from others when exposed to a variety of antimicrobial agents.
dc.format.extentxiv, 120 leaves : ill. ; 30 cm.en
dc.identifier.citationFoglia, G. (2007). The role of the gacs gene in the development of pseudomonas aeruginosa and pseudomonas chlororaphis small colony variants as a response to environmental stress (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/1386en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/1386
dc.identifier.urihttp://hdl.handle.net/1880/102387
dc.language.isoeng
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.titleThe role of the gacs gene in the development of pseudomonas aeruginosa and pseudomonas chlororaphis small colony variants as a response to environmental stress
dc.typemaster thesis
thesis.degree.disciplineBiological Sciences
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
ucalgary.thesis.accessionTheses Collection 58.002:Box 1714 520492231
ucalgary.thesis.notesUARCen
ucalgary.thesis.uarcreleaseyen
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