Colostrum-derived extracellular vesicles: potential multifunctional nanomedicine for alleviating mastitis

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dc.contributor.authorXiong, Yindi
dc.contributor.authorShen, Taiyu
dc.contributor.authorLou, Peng
dc.contributor.authorYang, Jingyue
dc.contributor.authorKastelic, John P.
dc.contributor.authorLiu, Jingping
dc.contributor.authorXu, Chuang
dc.contributor.authorHan, Bo
dc.contributor.authorGao, Jian
dc.date.accessioned2024-10-20T00:05:07Z
dc.date.available2024-10-20T00:05:07Z
dc.date.issued2024-10-16
dc.date.updated2024-10-20T00:05:07Z
dc.description.abstractAbstract Bovine mastitis is an infectious disease that causes substantial economic losses to the dairy industry worldwide. Current antibiotic therapy faces issues of antibiotic misuse and antimicrobial resistance, which has aroused concerns for both veterinary and human medicine. Thus, this study explored the potential of Colo EVs (bovine colostrum-derived extracellular vesicles) to address mastitis. Using LPS-induced murine mammary epithelial cells (HC11), mouse monocyte macrophages (RAW 264.7), and a murine mastitis model with BALB/C mice, we evaluated the safety and efficacy of Colo EVs, in vivo and in vitro. Colo EVs had favorable biosafety profiles, promoting cell proliferation and migration without inducing pathological changes after injection into murine mammary glands. In LPS-induced murine mastitis, Colo EVs significantly reduced inflammation, improved inflammatory scores, and preserved tight junction proteins while protecting milk production. Additionally, in vitro experiments demonstrated that Colo EVs downregulated inflammatory cytokine expression, reduced inflammatory markers, and attenuated NF-κB pathway activation. In summary, we inferred that Colo EVs have promise as a therapeutic approach for mastitis treatment, owing to their anti-inflammatory properties, potentially mediated through the NF-κB signaling pathway modulation. Graphical Abstract
dc.identifier.citationJournal of Nanobiotechnology. 2024 Oct 16;22(1):627
dc.identifier.urihttps://doi.org/10.1186/s12951-024-02926-2
dc.identifier.urihttps://hdl.handle.net/1880/120001
dc.language.rfc3066en
dc.rights.holderThe Author(s)
dc.titleColostrum-derived extracellular vesicles: potential multifunctional nanomedicine for alleviating mastitis
dc.typeJournal Article
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