White matter hyperintensities and smaller cortical thickness are associated with neuropsychiatric symptoms in neurodegenerative and cerebrovascular diseases

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dc.contributor.authorOzzoude, Miracle
dc.contributor.authorVarriano, Brenda
dc.contributor.authorBeaton, Derek
dc.contributor.authorRamirez, Joel
dc.contributor.authorAdamo, Sabrina
dc.contributor.authorHolmes, Melissa F.
dc.contributor.authorScott, Christopher J. M.
dc.contributor.authorGao, Fuqiang
dc.contributor.authorSunderland, Kelly M.
dc.contributor.authorMcLaughlin, Paula
dc.contributor.authorGoubran, Maged
dc.contributor.authorKwan, Donna
dc.contributor.authorRoberts, Angela
dc.contributor.authorBartha, Robert
dc.contributor.authorSymons, Sean
dc.contributor.authorTan, Brian
dc.contributor.authorSwartz, Richard H.
dc.contributor.authorAbrahao, Agessandro
dc.contributor.authorSaposnik, Gustavo
dc.contributor.authorMasellis, Mario
dc.contributor.authorLang, Anthony E.
dc.contributor.authorMarras, Connie
dc.contributor.authorZinman, Lorne
dc.contributor.authorShoesmith, Christen
dc.contributor.authorBorrie, Michael
dc.contributor.authorFischer, Corinne E.
dc.contributor.authorFrank, Andrew
dc.contributor.authorFreedman, Morris
dc.contributor.authorMontero-Odasso, Manuel
dc.contributor.authorKumar, Sanjeev
dc.contributor.authorPasternak, Stephen
dc.contributor.authorStrother, Stephen C.
dc.contributor.authorPollock, Bruce G.
dc.contributor.authorRajji, Tarek K.
dc.contributor.authorSeitz, Dallas
dc.contributor.authorTang-Wai, David F.
dc.contributor.authorTurnbull, John
dc.contributor.authorDowlatshahi, Dar
dc.contributor.authorHassan, Ayman
dc.contributor.authorCasaubon, Leanne
dc.contributor.authorMandzia, Jennifer
dc.contributor.authorSahlas, Demetrios
dc.contributor.authorBreen, David P.
dc.contributor.authorGrimes, David
dc.contributor.authorJog, Mandar
dc.contributor.authorSteeves, Thomas D. L.
dc.contributor.authorArnott, Stephen R.
dc.contributor.authorBlack, Sandra E.
dc.contributor.authorFinger, Elizabeth
dc.contributor.authorRabin, Jennifer
dc.contributor.authorTartaglia, Maria C.
dc.date.accessioned2023-06-25T00:03:13Z
dc.date.available2023-06-25T00:03:13Z
dc.date.issued2023-06-20
dc.date.updated2023-06-25T00:03:13Z
dc.description.abstractAbstract Background Neuropsychiatric symptoms (NPS) are a core feature of most neurodegenerative and cerebrovascular diseases. White matter hyperintensities and brain atrophy have been implicated in NPS. We aimed to investigate the relative contribution of white matter hyperintensities and cortical thickness to NPS in participants across neurodegenerative and cerebrovascular diseases. Methods Five hundred thirteen participants with one of these conditions, i.e. Alzheimer’s Disease/Mild Cognitive Impairment, Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, Parkinson’s Disease, or Cerebrovascular Disease, were included in the study. NPS were assessed using the Neuropsychiatric Inventory – Questionnaire and grouped into hyperactivity, psychotic, affective, and apathy subsyndromes. White matter hyperintensities were quantified using a semi-automatic segmentation technique and FreeSurfer cortical thickness was used to measure regional grey matter loss. Results Although NPS were frequent across the five disease groups, participants with frontotemporal dementia had the highest frequency of hyperactivity, apathy, and affective subsyndromes compared to other groups, whilst psychotic subsyndrome was high in both frontotemporal dementia and Parkinson’s disease. Results from univariate and multivariate results showed that various predictors were associated with neuropsychiatric subsyndromes, especially cortical thickness in the inferior frontal, cingulate, and insula regions, sex(female), global cognition, and basal ganglia-thalamus white matter hyperintensities. Conclusions In participants with neurodegenerative and cerebrovascular diseases, our results suggest that smaller cortical thickness and white matter hyperintensity burden in several cortical-subcortical structures may contribute to the development of NPS. Further studies investigating the mechanisms that determine the progression of NPS in various neurodegenerative and cerebrovascular diseases are needed.
dc.identifier.citationAlzheimer's Research & Therapy. 2023 Jun 20;15(1):114
dc.identifier.urihttps://doi.org/10.1186/s13195-023-01257-y
dc.identifier.urihttps://hdl.handle.net/1880/116662
dc.identifier.urihttps://dx.doi.org/10.11575/PRISM/41505
dc.language.rfc3066en
dc.rights.holderThe Author(s)
dc.titleWhite matter hyperintensities and smaller cortical thickness are associated with neuropsychiatric symptoms in neurodegenerative and cerebrovascular diseases
dc.typeJournal Article
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