A Tale of Two Methods: Combining Near-Infrared Spectroscopy with MRI for Studies of Brain Oxygenation and Metabolism

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dc.contributor.authorDunn, Jeffrey F.
dc.contributor.authorNathoo, Nabeela
dc.contributor.authorYang, Runze
dc.date.accessioned2017-03-17T22:55:19Z
dc.date.available2017-03-17T22:55:19Z
dc.date.issued2014-03-22
dc.description.abstractCombining magnetic resonance imaging (MRI) with near-infrared spectroscopy (NIRS) leads to excellent synergies which can improve the interpretation of either method and can provide novel data with respect to measuring brain oxygenation and metabolism. MRI has good spatial resolution, can detect a range of physiological parameters and is sensitive to changes in deoxyhemoglobin content. NIRS has lower spatial resolution, but can detect, and with specific technologies, quantify, deoxyhemoglobin, oxyhemoglobin, total hemoglobin and cytochrome oxidase. This paper reviews the application of both methods, as a multimodal technology, for assessing changes in brain oxygenation that may occur with changes in functional activation state or metabolic rate. Examples of hypoxia and ischemia are shown. Data support the concept of reduced metabolic rate resulting from hypoxia/ischemia and that metabolic rate in brain is not close to oxygen limitation during normoxia. We show that multimodal MRI and NIRS can provide novel information for studies of brain metabolism.en_US
dc.description.grantingagencyNSERC; CIHR; endMS; MS Society of Canada; AIHSen_US
dc.description.refereedYesen_US
dc.identifier.citationDunn J.F., Nathoo N., Yang R. (2014) A Tale of Two Methods: Combining Near-Infrared Spectroscopy with MRI for Studies of Brain Oxygenation and Metabolism. In: Swartz H., Harrison D., Bruley D. (eds) Oxygen Transport to Tissue XXXVI. Advances in Experimental Medicine and Biology, vol 812. Springer, New York, NYen_US
dc.identifier.doi10.1007/978-1-4939-0620-8_9
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33477
dc.identifier.issn0065-2598
dc.identifier.urihttp://hdl.handle.net/1880/51881
dc.language.isoenen_US
dc.publisherKluweren_US
dc.publisher.corporateUniversity of Calgary
dc.publisher.departmentRadiologyen_US
dc.publisher.facultyMedicineen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.subjectMRIen_US
dc.subjectnear-infrareden_US
dc.subjectbrainen_US
dc.subjecthypoxiaen_US
dc.subjectmultimodel imagingen_US
dc.titleA Tale of Two Methods: Combining Near-Infrared Spectroscopy with MRI for Studies of Brain Oxygenation and Metabolismen_US
dc.typejournal article
thesis.degree.disciplineRadiology / Physiology / Clinical Neurosciences
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