Maternal cortisol during pregnancy is related to infant cardiac vagal control

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dc.contributor.authorRash, Joshua
dc.contributor.authorCampbell, Tavis
dc.contributor.authorLetourneau, Nicole
dc.contributor.authorGiesbrecht, Gerald
dc.date.accessioned2015-11-02T23:53:40Z
dc.date.available2015-11-02T23:53:40Z
dc.date.issued2015-04
dc.descriptionAuthor's accepted manuscript deposited according to Elsevier sharing policies http://www.elsevier.com/about/company-information/policies/policy-faq October 26, 2015en_US
dc.description.abstractBackground: Prenatal exposure to maternal psychological distress and glucocorticoids result in neurobiological adaptations within the fetus that increase risk for developing exaggerated emotional, behavioral, and stress responses to novelty and challenges in childhood. The current study investigated the influence of maternal depressed mood and cortisol during pregnancy on infant cardiac vagal control (CVC) to standardized laboratory challenge tasks. Methods: The sample comprised 194 women and their infants. Maternal reports of depressed mood and salivary cortisol were assessed at 14 and 32 weeks gestational age. Linear regression was used to examine associations between maternal measures during early and late pregnancy, and infant CVC indexed via respiratory sinus arrhythmia (RSA) at rest and in response to laboratory tasks designed to elicit frustration when infants were 6 months of age. It was hypothesized that maternal depressed mood and cortisol would be associated with lower basal RSA and smaller decreases in RSA from baseline to challenge. Results: A significant decrease in infant RSA from baseline to frustration tasks indicated that laboratory tasks elicited a reliable decrease in RSA from baseline to frustration among infants which is characterized by reduction in vagal efferent activity on the heart in response to challenge. Higher maternal cortisol, but not depressed mood, was associated with lower basal RSA and greater decrease in RSA from baseline to frustration. Associations between maternal cortisol and infant basal RSA were observed for both early and late pregnancy whereas the associations between prenatal cortisol and decrease in RSA from baseline to frustration were observed for early, but not late, pregnancy. Conclusions: Maternal cortisol during pregnancy was associated with infant CVC at 6-months of age. Such influences may have enduring impacts on the child and important implications for the development of physical and mental health outcomes.en_US
dc.description.refereedYesen_US
dc.description.sponsorshipThis research was supported in part by grants from Alberta Innovates Health Solutions, the Canadian Institutes of Health Research, the Alberta Centre for Child, Family and Community Research, and the Alberta Children's Hospital Research Institute. The sources of funding had no role in the study design, in the collection, analysis or interpretation of data; in writing the manuscript; or Financial Disclosuresen_US
dc.identifier.citationRash, J., Campbell, T., Letourneau, N., Giesbrecht, G.F. (2015). Maternal cortisol during pregnancy is related to infant cardiac vagal control. Psychoneuroendocrinology,54(April), 78–89.en_US
dc.identifier.doi10.1016/j.psyneuen.2015.01.024
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33641
dc.identifier.urihttp://hdl.handle.net/1880/51005
dc.language.isoenen_US
dc.publisherPsychoneuroendocrinologyen_US
dc.publisher.corporateUniversity of Calgary
dc.publisher.departmentDepartment of Psychologyen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.publisher.urlhttp://www.journals.elsevier.com/psychoneuroendocrinology/en_US
dc.rightsAttribution Non-Commercial No Derivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCardiac Vagal Controlen_US
dc.subjectFetal Programmingen_US
dc.subjectDepressed Mooden_US
dc.subjectCortisolen_US
dc.subjectRespiratory Sinus Arrhythmiaen_US
dc.titleMaternal cortisol during pregnancy is related to infant cardiac vagal controlen_US
dc.typejournal article
thesis.degree.disciplinePaediatrics
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