Krabbe disease: Two cases of multidisciplinary symptom management

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dc.contributor.authorYang, David
dc.contributor.authorGnanakumar, Vithya
dc.contributor.authorSpencer, Adam
dc.contributor.authorLivingstone, Margaret
dc.date.accessioned2021-04-09T21:15:35Z
dc.date.available2021-04-09T21:15:35Z
dc.date.issued2021-04-08
dc.date.updated2021-04-07T19:18:39Z
dc.description.abstractWe present the comprehensive, multidisciplinary symptom management of two patients with infantile Krabbe disease. Krabbe disease is a rare autosomal recessive neurodegenerative condition, and is ultimately fatal. Initial symptoms and subsequent diagnoses of our patients are discussed. Supportive care for patients with this disease prioritizes symptomatic management of pain and irritability. Pharmacological management strategies are discussed including the implementation of various medications and doses, and proposed medication mechanisms of action in the context of Krabbe disease. Adverse effects of the introduction of morphine are discussed in one patient. Non-pharmacological management strategies including therapy programs are also discussed including the utilization of splinting, seating, and positioning. Patients with Krabbe disease benefit from a comprehensive team of multidisciplinary medical professionals. en_US
dc.identifier.citationYang, D., Gnanakumar, V., Spencer, A., Livingstone, M. (2021). Krabbe disease: Two cases of multidisciplinary symptom management [Manuscript submitted for publication]. Cumming School of Medicine, University of Calgary.en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/38711
dc.identifier.urihttp://hdl.handle.net/1880/113210
dc.language.isoengen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.hasversionsubmittedVersionen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.subjectMyelin sheath--Diseasesen_US
dc.titleKrabbe disease: Two cases of multidisciplinary symptom managementen_US
dc.typejournal articleen_US
ucalgary.item.requestcopytrueen_US
ucalgary.scholar.levelFacultyen_US
ucalgary.scholar.levelOtheren_US
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