Aggressive Subtypes of Laryngeal Chondrosarcoma and their Clinical Behavior: A Systematic Review

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dc.contributor.authorPiazza, Cesare
dc.contributor.authorMontenegro, Claudia
dc.contributor.authorTomasoni, Michele
dc.contributor.authorLeivo, Ilmo
dc.contributor.authorStenman, Göran
dc.contributor.authorAgaimy, Abbas
dc.contributor.authorSimpson, Roderick H. W.
dc.contributor.authorZidar, Nina
dc.contributor.authorFerlito, Alfio
dc.date.accessioned2025-01-12T01:04:55Z
dc.date.available2025-01-12T01:04:55Z
dc.date.issued2025-01-05
dc.date.updated2025-01-12T01:04:55Z
dc.description.abstractAbstract Introduction Laryngeal chondrosarcoma (CS) is a rare indolent malignant tumor. High-grade (G3), dedifferentiated (DD), and myxoid (MY) CSs are considered more aggressive subtypes due to their metastatic potential and relatively poor outcomes. The aim of this systematic review is to evaluate treatment modalities and survival outcomes in patients affected by these rarer CS subtypes. Methods Papers published from January 1, 2000, to August 25, 2024, describing cases of laryngeal G3, DD, and MY CS were included. Results A total of 38 patients (15 G3, 13 DD, and 10 MY) were selected. Cricoid cartilage was the most common site of origin. Total laryngectomy (TL) was often performed. Primary conservative approaches in 42.8% of patients were followed by loco-regional recurrence. Conclusions Aggressive subtypes of CS require a radical approach because of the higher rate of loco-regional and distant recurrences compared to low-grade CS. TL with radical intent is the most common treatment, and adjuvant therapy should be considered after careful multidisciplinary discussion.
dc.identifier.urihttps://doi.org/10.1007/s40487-024-00323-1
dc.identifier.urihttps://hdl.handle.net/1880/120432
dc.language.rfc3066en
dc.rights.holderThe Author(s)
dc.titleAggressive Subtypes of Laryngeal Chondrosarcoma and their Clinical Behavior: A Systematic Review
dc.typeJournal Article
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