Unfolding of membrane ruffles of in situ chondrocytes under compressive loads
Date
2016
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Orthopaedic Research
Abstract
Impact loading results in chondrocyte death. Previous studies implicated high tensile strain rates in chondrocyte membranes as the cause of impact-induced cell deaths. However, this hypothesis relies on the untested assumption that chondrocyte membranes unfold in vivo during physiological tissue compression, but do not unfold during impact loading. Although membrane unfolding has been observed in isolated chondrocytes during osmotically induced swelling and mechanical compression, it is not known if membrane unfolding also occurs in chondrocytes embedded in their natural extracellular matrix. This study was aimed at quantifying changes in membrane morphology of in situ superficial zone chondrocytes during slow physiological cartilage compression.
Description
Keywords
Cell and Molecular Imaging, Mechanobiology, Osteoarthritis, membrane resevoir, articular cartilage, impact loading, knee joint
Citation
Moo, E. K., & Herzog, W. (2016). Unfolding of membrane ruffles of in situ chondrocytes under compressive loads. Journal of Orthopaedic Research.