Unfolding of membrane ruffles of in situ chondrocytes under compressive loads

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dc.contributor.authorHerzog, Walter
dc.contributor.authorMoo, Eng Kuan
dc.date.accessioned2016-06-21T18:48:14Z
dc.date.available2016-06-21T18:48:14Z
dc.date.issued2016
dc.description.abstractImpact loading results in chondrocyte death. Previous studies implicated high tensile strain rates in chondrocyte membranes as the cause of impact-induced cell deaths. However, this hypothesis relies on the untested assumption that chondrocyte membranes unfold in vivo during physiological tissue compression, but do not unfold during impact loading. Although membrane unfolding has been observed in isolated chondrocytes during osmotically induced swelling and mechanical compression, it is not known if membrane unfolding also occurs in chondrocytes embedded in their natural extracellular matrix. This study was aimed at quantifying changes in membrane morphology of in situ superficial zone chondrocytes during slow physiological cartilage compression.en_US
dc.description.refereedYesen_US
dc.identifier.citationMoo, E. K., & Herzog, W. (2016). Unfolding of membrane ruffles of in situ chondrocytes under compressive loads. Journal of Orthopaedic Research.en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/29063
dc.identifier.otherJOR-15-0838.R1
dc.identifier.urihttp://hdl.handle.net/1880/51398
dc.language.isoenen_US
dc.publisherJournal of Orthopaedic Researchen_US
dc.publisher.departmentHuman Performance Laboratoryen_US
dc.publisher.facultyKinesiologyen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.subjectCell and Molecular Imagingen_US
dc.subjectMechanobiologyen_US
dc.subjectOsteoarthritisen_US
dc.subjectmembrane resevoiren_US
dc.subjectarticular cartilageen_US
dc.subjectimpact loadingen_US
dc.subjectknee jointen_US
dc.titleUnfolding of membrane ruffles of in situ chondrocytes under compressive loadsen_US
dc.typejournal article
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