Prevalence, Risk Factors and Short Term Outcomes of Hypophosphatemia among Very Low Birth Weight Infants: An Exploratory Pilot Study
Abstract
Background: Health care professionals face challenges in improving survival rates among very low birth infants who are at risk of hypophosphatemia. We aimed to identify the prevalence and predictive factors of hypophosphatemia.
Methods: Prospective, exploratory pilot study of 106 infants admitted to intensive care unit at Foothills Hospital, Calgary between October 1, 2011 and June 1, 2012.
Results: The prevalence of hypophosphatemia was 77%. Hypophosphatemic infants had significantly lower birth weight (p< 0.001) and gestational age (p< 0.001). Furthermore, respiratory distress syndrome (RDS) (p = 0.002), intraventricular hemorrhage (IVH) ≥ grade III (p =0.020), and hyperglycemia (p = 0.013) were more frequent among hypophosphatemic infants. Birth weight modified the association between RDS, IVH, hyperglycemia and hypophosphatemia.
Conclusion: Hypophosphatemia is common in premature infants. Further research should determine whether premature birth and the associated metabolic consequences as well as the severity of the accompanying comorbidities increase the risk of hypophosphatemia.
Description
Keywords
Medicine and Surgery
Citation
Al-Wassia, H. (2017). Prevalence, Risk Factors and Short Term Outcomes of Hypophosphatemia among Very Low Birth Weight Infants: An Exploratory Pilot Study (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27425